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Theoretical model structure of CYP2B4 showing surfaces distal and proximal to the heme thiolate ligand. The membrane anchor is not shown. The regions colored yellow are segments corresponding to regions in the CYP2C5 structure reported to be hydrophobic (2). Segments colored red are anti-peptide antibody binding epitopes known to bind the membrane-bound form of CYP2B4 or CYP2B5. Residues colored blue are believed to be involved in electrostatic interaction with P450 reductase.
