Table 3.
BRI and the multiplicative and additive interactions of Ascorbic Acid intake and sex on biological aging
| Ascorbic Acid intake | Sex | |
|---|---|---|
| Multiplicative interaction | ||
| Multiplicative scale | 0.83(0.72 ~ 0.96) | 1.72(1.48 ~ 1.99) |
| P | 0.01 | < 0.001 |
| Additive interaction | ||
| RERI (95% CI) | −0.37 (−0.61 ~ −0.14) | 0.20(0.05 ~ 0.36) |
| AP (95% CI) | −0.22 (−0.37 ~ −0.08) | 0.18(0.04 ~ 0.32) |
| SI (95% CI) | 0.65(0.5 ~ 0.84) | NA |
RERI Relative excess risk due to interaction, AP Attributable proportion, SI Synergy index, CI Confidence interval
This table provides insights into the interaction effects of Ascorbic Acid intake and sex on biological aging as indicated by BRI. The multiplicative interaction results suggest that the impact of BRI on biological aging is modified by both Ascorbic Acid intake and sex. Specifically, the multiplicative scale for Ascorbic Acid intake, with a value less than 1, implies a reduced effect on biological aging when Ascorbic Acid intake is considered, indicating a potential protective role. Conversely, the multiplicative scale for sex, with a value greater than 1, suggests that biological aging is exacerbated in one sex compared to the other
The additive interaction measures provide further detail on how these factors influence biological aging independently of their main effects. The RERI values indicate that the joint effect of BRI, Ascorbic Acid intake, and sex on biological aging deviates from what would be expected if their effects were simply additive. The negative RERI for Ascorbic Acid intake suggests that the combined effect is less than additive, possibly due to a protective interaction, while the positive RERI for sex indicates a greater than additive effect, suggesting a synergistic interaction that enhances the impact of BRI on biological aging
The AP values quantify the proportion of the biological aging effect that is attributable to the interaction between BRI and the respective factors. The negative AP for Ascorbic Acid intake suggests that interactions reduce the risk of biological aging, while the positive AP for sex indicates that interactions increase this risk