Table 2.

The role of the C/EBPβ isoform in inflammation.

C/EBPβ isoforms					Reference
Structural Features		LAP1	LAP2	LIP
		Full-length N-terminal transactivation domain (TAD)	Lacking 21 amino acids at the N-terminal TAD and partially regulatory	Completely lacking the N-terminal TAD and Lacking most of the negative regulatory domain	(30)
Primary Functions		Increase transcriptional activity	Increase transcriptional activity	Inhibit transcriptional activity	(31)
Diseases Mechanisms	Lupus nephritis	C/EBPβ-LAP upregulates AIM2 inflammasome activity by promoting the transcriptional expression of AIM2 and CASPASE1 through direct promoter binding		C/EBPβ-LIP suppresses IRAG expression at the transcriptional level, enhancing Ca²+ release and subsequent AIM2 inflammasome activation	(71)
	Chronic inflammation	LAP isoforms promote inflammation by activating the transcription of pro-inflammatory genes, including IL-6 and TNFα		LIP reduces inflammation by blocking LAP	(77)