Figure 6.

Gene transcripts upregulated by LIGHT, IL-13, and IL-17 are represented in lung fibroblast clusters from ILD. Fourteen different transcriptional profiles (clusters 0–13) from lung ILD fibroblasts, defined by Korsunsky et al.,⁴ were assessed: for gene transcripts of LIGHT, IL13, or IL17 or their receptors (A) or for gene transcripts upregulated in HPFs associated with LIGHT signaling (B); or for other gene transcripts upregulated in healthy pulmonary fibroblasts by LIGHT alone (C), LIGHT alone shared with IL-13 alone (D), IL-13 alone (E), LIGHT alone shared with IL-17 alone (F), and IL-17 alone (G), taken from data in Fig. 2 and found in red circles of Venn diagrams. Dot plots show scaled mean expression (blue to red color) integrated with percentage of cells expressing each transcript (size of dots).