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. Author manuscript; available in PMC: 2025 Sep 21.
Published in final edited form as: Am J Prev Med. 2025 Jul 29;69(4):107738. doi: 10.1016/j.amepre.2025.107738

Daily walking and mortality in racially and socioeconomically diverse US adults

Lili Liu 1, Guochong Jia 1, Martha J Shrubsole 1, Wanqing Wen 1, Shaneda Warren Andersen 2, Staci L Sudenga 1, Wei Zheng 1,*
PMCID: PMC12449391  NIHMSID: NIHMS2106911  PMID: 40744164

Abstract

Introduction:

While the health benefits of daily walking are well-established, limited research has investigated effects of factors such as walking pace on mortality, particularly in low-income and Black/African-American populations.

Methods:

Data from the Southern Community Cohort Study were used, including information from nearly 85,000 predominantly low-income and Black individuals recruited during 2002–2009 across 12 southeastern US states. Participants provided baseline information on daily walking pace and time, demographic information, lifestyle factors, and health status. Mortality data were collected until December 31, 2022. Analysis was conducted from September 2023 to June 2024.

Results:

Over a median follow-up of 16.7 (2.0–20.8) years, 26,862 deaths occurred. Significant associations were found between all-cause mortality and daily fast walking time. Fast walking as little as 15 minutes a day was associated a nearly 20% reduction in total mortality (HR: 0.81, 95% CI: 0.75–0.87), while only a 4% reduction in mortality (HR: 0.96, 95% CI: 0.91–1.00) was found in association with more than three hours of daily slow walking. Fast walking was independently associated with reduced mortality, regardless of the leisure-time physical activity levels. The inverse association was more pronounced for mortality due to cardiovascular diseases than cancers. Participants with baseline comorbidities had larger risk reductions compared to their generally healthy counterparts, although all individuals benefited from fast walking.

Conclusions:

Regular walking, particularly fast walking, was associated with reduced mortality. These findings underscore the importance of promoting fast walking as a feasible and effective strategy to improve health outcomes and address health disparities among low socioeconomic populations.

INTRODUCTION

Regular walking is widely recognized for its significant benefits on overall health and well-being. 1–3 Extensive research has examined various dimensions of walking behaviors, including walking pace, 4,5 step count, 6,7 and weekly frequency, 8 all of which consistently demonstrate strong associations with mortality. Moderate intensity or brisk walking has been associated with reduced mortality and is therefore included in the American Heart Association recommendations for physical activity. Several previous studies suggested that replacing sitting behaviors with light-intensity walking may reduce the levels of postprandial insulin and glucose 9,10 and improve vascular-inflammatory markers (TNF-α, IL-1β, PAI-1 and fibrinogen) among patients with type 1 diabetes. 11 A recent randomized crossover trial reported that light-intensity walking could reduce the diastolic blood pressure among young obese adults. 12 A recent study found that >1.5 hours of daily light-intensity physical activities was significantly associated with a 30% reduction in mortality among older adults; however, this study did not specifically evaluate light-intensity walking. 13 Furthermore, a recent meta-analysis found no significant effects of either standing interruptions or light-intensity walking on blood pressure reduction, 10 Given inconsistent results from previous studies, additional research is needed to investigate whether light-intensity walking may reduce mortality.

Existing literature on walking and other leisure-time physical activity (LTPA) primarily focuses on middle-to-high-income white populations, 2,4 lacking representation of low-income, particularly low-income Black, individuals. Walking behaviors may differ significantly between individuals from low-income and higher-income backgrounds. 14 Low-income populations often face economic constraints and are more likely to reside in impoverished, highly polluted communities with limited access to safe walking spaces.15,16 Additionally, these populations tend to have a higher prevalence of lifestyle behaviors that may increase disease risk and mortality, such as lower quality diet, cigarette smoking, and heavy alcohol consumption. 17,18 At the same time, there are other challenges for individuals with low income such as lack of access to health insurance or health care that may also increase mortality. 19 These factors collectively contribute to an increased mortality within low-income individuals and may potentially elucidate the racial disparities observed in longevity.20 Few studies, especially those with large sample sizes and long-term follow-up, have adequately assessed the association between daily walking and mortality outcomes in racial/ethnic minority populations in the US disproportionately affected by low income.

To bridge this research gap, data from the Southern Community Cohort Study (SCCS) were used to investigate the association between daily walking and overall/cause-specific mortality, while also exploring potential modifying effects of behavioral risk factors. The SCCS is a large prospective cohort study designed to investigate the determinants of racial disparities in cancer and other chronic diseases among underserved populations in the United States. 21 Notably, more than half of the study participants reported an annual income of less than $15,000 at enrollment, with approximately two-thirds of the cohort consisting of Black participants. This unique cohort provides an exceptional opportunity to evaluate the association between daily walking and mortality within a racially diverse low-income population.

METHODS

Study Population

The SCCS was described in detail previously. 21 In brief, the study enrolled approximately 85,000 participants aged 40 to 79 during 2002–2009 who had not undergone cancer treatment within one year prior to the study baseline. The majority of participants (86%) were recruited in collaboration with community health centers (CHCs) serving low-income populations across 12 southeastern states. The remaining 14% of participants were recruited through stratified random sampling from residents within the same 12 states. Baseline data, including daily walking, sociodemographic and lifestyle factors, and medical history, were collected using structured questionnaires. The SCCS was approved by institutional review boards at Vanderbilt University Medical Center and Meharry Medical College, and all participants provided written informed consent. For the current analysis, participants who died within the first two years after completing the baseline survey to reduce potential bias due to reverse causality (n = 1,867) or with missing values for daily walking (n = 3,072) were excluded, leading to a final study sample of 79,856.

Measures

During the baseline survey, participants reported the average amount of time per day (minutes) they typically spend “walking slowly (such as moving around, walking at work, walking the dog, or engaging in light exercise)” and “walking fast (such as climbing stairs, brisk walking, or exercising)”. Participants provided numeric values ranging from 0 to 720 minutes. The questionnaire was tested for validity and showed fair to moderate test-retest reliability. 22 To address sparse distributions for both slow and fast walking, participants were classified into four groups: no walking (0), >0 to 30 minutes, >30 minutes to 60 minutes, and >60 minutes. The inclusion of the 30-minute category aligns with the minimum recommendation for health benefits from previous studies. 23 Associations for fast walking at finer scale (i.e., 15 minutes) were also explored.

Five behavioral factors with well-established associations with mortality were measured at baseline: cigarette smoking, alcohol drinking, LTPA, sedentary behavior, and diet quality. Briefly, participants were classified into four smoking status groups: never, former, current light, and current heavy. Participants who currently smoked ≥20 years and ≥20 cigarettes/day were classified into current heavy smoking group; otherwise, they were considered current light. Participants reporting >0 drink/day but ≤1 for women or ≤2 for men were classified into moderate drinking group; otherwise, they were considered heavy drinking. LTPA was defined as the total of moderate activities (such as bowling, dancing, golfing, or softball) and vigorous sports (such as jogging, aerobics, bicycling, tennis, swimming, weightlifting, or basketball). Standard metabolic equivalents (MET) were calculated using standard methods described in the Compendium of Physical Activity, specifically MET-hours= 5.0*moderate + 8.0*vigorous. 22 LTPA was categorized into three groups: inactive, fairly active, and active. Participants without any LTPA were classified as inactive, while those reporting <7.5 MET-hours per week were considered fairly active, and those reporting ≥7.5 MET-hours per week (equivalent to the guideline recommendation of ≥150 minutes of moderate activity or ≥75 minutes of vigorous activity per week) were considered active. 24 Total daily sitting time (hours) was used to assess sedentary behaviors. A food frequency questionnaire was used to assess usual dietary intakes, and the diet quality was measured using the Healthy Eating Index (HEI-2010), which evaluates concordance with the 2010 US Dietary Guidelines for Americans. 25 To measure an individual’s overall lifestyle, five health behaviors were then combined into a composite lifestyle score for each individual, by taking the sum of the negative of regression coefficients associated with all-cause mortality from the fully adjusted model. 26 This coefficient-based score ranged from −0.06 to 1.27, with a higher value representing a healthier lifestyle.

Information regarding vital status and cause of death was obtained through linkage of the cohort to the National Death Index until December 31, 2022. 21 The primary outcomes for this study are all-cause mortality and mortality due to major causes. Causes of death were grouped according to ICD-10 codes: cardiovascular disease (CVD) (I00 - I69), cancers (C00 - C97), other non-CVD and non-cancer disease causes (deaths with codes starting D-N), as well as external causes such as accidents and injuries (deaths with codes starting V, W, X, or Y). Additionally, site-specific mortality for CVD was classified as follows due to their high prevalences 27: ischemic heart diseases (I20-I25), heart failure (I50), cerebrovascular diseases (I60-I69), and others.

Statistical Analysis

Hazard ratios (HR) and 95% confidence interval (CI) were estimated using Cox proportional hazard regression to assess the associations between daily walking time and all-cause or cause-specific mortality, with follow-up duration as the time scale, stratified by birth year (categorized into 10-year groups). The follow-up stopped at death, loss to follow-up or December 31, 2022, whichever came first. To account for competing risks, sub-distribution hazard models were used for cause-specific mortality. 28 The base model (Model 1) adjusted for enrollment source (CHC, general population), sex (male, female), racial group (Black, white, other), education (<high school, high school, >high school), marital status (married, divorced/separated, widowed, single), household income (<$15,000, $15,000 to $24,999, $25,000 to $49,999, or ≥$50,000), self-reported employment status (yes, no), and health insurance (insured, none). Model 2 included additional covariates to assess the impacts of lifestyle factors and baseline comorbidities (sum of hypertension, diabetes, myocardial infarction, and stroke): five lifestyle factors mentioned above, body mass index (BMI; <25, 25 to 30, >30), and baseline comorbidities (0, 1, 2, ≥3). Model 3 involved mutual adjustment of slow walking and fast walking. Missing values (0.3 – 5.8%) were imputed using multiple imputation chained equations (MICE, M=1) with the assumption of missing at random. 29 Frequency distributions of baseline characteristics were tabulated and compared across fast walking time groups. Trend tests were conducted by treating the categorical walking variables as continuous in the model. The proportional hazards assumption was evaluated graphically using the Schoenfeld residuals and confirmed. Sensitivity analyses were conducted among individuals without missing values and included those with missing walking values and those who died within the first two years. Stratification analyses were conducted by sex, race, household income, BMI, smoking status, and baseline comorbidities. All statistical analyses were performed using R 4.3.2. A Bonferroni-corrected p-value < 0.008 (0.05/6) was considered statistically significant in the analyses of potential interaction effects given six tests were performed. For the main analysis, however, no multiple comparison adjustment was made as specific study hypotheses were tested.

RESULTS

Among the final study sample of 79,856, a total of 26,862 deaths were recorded during a median follow-up of 16.7 (2.0–20.8) years, including deaths due to CVD (n = 13,486), cancer (n = 6,378), other diseases (n = 5,408), and external causes (n = 1,590). At baseline, nearly half of the participants (47.9%) reported no fast walking in their daily routine, while around one-third (34.2%) engaged in slow walking for over three hours every day (Table 1). Participants with longer daily fast walking times tended to be younger, enrolled from a CHC, male, Black, and single. They also tended to have a lower level of education, household income, insurance coverage, and BMI; higher levels of employment, tobacco smoking, alcohol consumption, LTPA, and sitting time; lower quality diet; and fewer chronic diseases at baseline.

Table 1.

Selected baseline characteristics of participants by daily fast walking, the Southern Community Cohort Study

Characteristics Whole cohort (N=79,856) Daily fast walking time, minutes f
0 (n=38,249) > 0 to 30 (n=10,322) > 30 to 60 (n=13,581) > 60 (n=17,704)
Age, years 52.70 (8.75) 53.94 (9.11) 52.96 (8.53) 52.01 (8.41) 50.39 (7.77)
Enrollment source
 Community health center 85.47 88.29 75.45 81.26 88.45
 General population 14.53 11.71 24.55 18.74 11.55
Sex, Female 59.62 62.00 61.40 58.26 54.46
Racial groups
 White 30.40 29.91 37.99 32.39 25.53
 Black 65.57 66.35 57.52 63.53 70.16
 Other 4.02 3.74 4.50 4.08 4.31
Marital status
 Married 35.85 34.37 43.00 38.77 32.61
 Separated/divorced 33.43 34.10 30.37 32.30 34.62
 Widowed/Single 30.72 31.52 26.63 28.93 32.76
Education
 < High school 28.20 34.03 18.54 21.25 26.56
 High school 38.55 38.81 33.96 37.57 41.42
 > High school 33.25 27.16 47.50 41.18 32.02
Annual household income, $
 < 15,000 54.26 62.34 41.22 44.55 51.85
 15,000 – 24,999 21.14 19.94 19.35 21.95 24.15
 25,000 – 49,999 14.47 11.66 18.55 17.84 15.59
 ≥ 50,000 10.13 6.06 20.88 15.66 8.41
Employment status, yes 40.43 29.40 51.29 47.82 52.25
Health insurance, yes 60.86 62.45 66.84 61.39 53.52
Obesity a 44.64 51.24 44.09 40.17 34.11
Current smoked 40.52 40.79 30.33 37.36 48.31
Heavy alcohol drinking 18.85 16.28 15.91 19.88 25.32
LTPA levels, MET-hour/week 8.44 (18.80) 4.51 (13.96) 9.26 (17.54) 11.66 (20.15) 14.01 (24.71)
Daily sitting time, hours 9.32 (5.06) 9.33 (5.11) 8.99 (4.61) 9.24 (4.71) 9.55 (5.43)
Healthy eating index b 57.83 (12.04) 56.83 (11.89) 60.18 (12.31) 59.42 (12.17) 57.39 (11.78)
Healthy lifestyle score c 0.49 (0.30) 0.48 (0.30) 0.56 (0.29) 0.52 (0.30) 0.46 (0.31)
Comorbidity index d 0.94 (0.89) 1.10 (0.92) 0.88 (0.86) 0.80 (0.84) 0.72 (0.80)

Notes: Results are presented as percentage or mean (standard deviation). LTPA: leisure-time physical activity. MET: metabolic equivalents.

a

Having a body mass index > 30 kg/m2.

b

A composite diet quality score of adherence to the US Dietary Guidelines for Americans 2010, ranging from 0 to 100.

c

A lifestyle score derived from the regression coefficients associated with all-cause mortality of smoking status, alcohol intake, and healthy eating index.

d

A composite score based on the presence or absence of hypertension, diabetes, myocardial infarction, stroke, and cancers.

f

Differences across walking time groups were statistically significant at P < 0.001 for all comparisons.

Significant associations between daily fast walking time and all-cause mortality were found, but not for slow walking (Table 2). Participants who engaged in more than three hour of slow walking experienced a 4% lower mortality (HR: 0.96, 95% CI: 0.91–1.00), although the association was not statistically significant (P=0.06). Notably, participants walking fast experienced a significant risk reduction with as little as 15 minutes of walking per day (HR: 0.81, 95% CI: 0.75–0.87). Additional adjustment of lifestyle factors slightly attenuated the associations for both slow and fast walking time. Still, the association remained highly significant for fast walking (Model 2), and no major differences were seen for mutual adjustment (Model 3).

Table 2.

Associations of daily walking by pace with all-cause mortality, the Southern Community Cohort Study

Daily walking time, minutes No. of participants No. of Deaths HR (95%CI) a HR (95%CI) b HR (95%CI) c
Slow walking
 0 6,444 2,235 1 (Ref.) 1 (Ref.) 1 (Ref.)
 > 0 to 30 7,085 2,536 0.99 (0.93, 1.04) 1.00 (0.94, 1.06) 0.99 (0.93, 1.05)
 > 30 to 60 15,372 5,308 0.97 (0.92, 1.02) 0.98 (0.93, 1.03) 0.98 (0.93, 1.03)
 > 60 50,955 16,783 0.96 (0.92, 1.01) 0.97 (0.93, 1.02) 0.96 (0.92, 1.01)
  > 60 to 180 23,687 8,319 0.97 (0.93, 1.02) 0.99 (0.94, 1.04) 0.99 (0.94, 1.05)
  > 180 27,268 8,464 0.96 (0.91, 1.00) 0.96 (0.92, 1.01) 0.96 (0.92, 1.01)
   P-trend 0.088 0.144 0.115
Fast walking
 0 38,249 15,602 1 (Ref.) 1 (Ref.) 1 (Ref.)
 > 0 to 30 10,322 2,746 0.77 (0.73, 0.80) 0.82 (0.79, 0.86) 0.82 (0.79, 0.86)
  > 0 to 15 2,401 678 0.81 (0.75, 0.87) 0.86 (0.80, 0.93) 0.86 (0.80, 0.93)
  > 15 to 30 7,921 2,068 0.75 (0.72, 0.79) 0.81 (0.77, 0.85) 0.81 (0.77, 0.85)
 > 30 to 60 13,581 3,657 0.77 (0.74, 0.79) 0.82 (0.79, 0.85) 0.82 (0.79, 0.85)
 > 60 17,704 4,857 0.80 (0.77, 0.82) 0.84 (0.81, 0.87) 0.84 (0.80, 0.89)
   P-trend < 0.001 < 0.001 < 0.001

Notes: P trends were calculated across four categories (0, >0 to 30, >30 to 60, and >60).

a

Model 1: Adjusted for enrollment source, age, sex, race, education, marital status, household income, employment, and insurance status;

b

Model 2: Additionally adjusted for smoking status, alcohol intake, diet quality, leisure-time physical activity, daily sitting time, body mass index, and comorbidities;

c

Model 3: Additional mutual adjustment for slow or fast walking time.

Sensitivity analyses, conducted both with participants having complete data and including individuals who died within the first two years, yielded consistent results for the association of time spent on slow or fast walking with overall mortality (Appendix Table 1). Similar association patterns of daily fast walking time were observed for all cause-specific mortality outcomes (Figure 1). The associations, however, were most pronounced for CVD (HR = 0.80; 95%CI: 0.76–0.84 for >60 vs. inactive) and followed by other diseases, cancers and external causes. Among the causes of CVD, heart diseases, especially ischemic heart diseases and heart failure, showed stronger associations (Appendix Figure 1).

Figure 1.

Figure 1.

Associations of daily walking time by pace with cause-specific mortality, the Southern Community Cohort Study.

Notes: HRs were adjusted for enrollment source, age, sex, race, education, marital status, household income, employment, insurance status, smoking status, alcohol intake, diet quality, daily sitting time, body mass index, and comorbidities when applicable. CVD: Cardiovascular diseases.

Stratified analyses revealed significant multiplicative interactions of fast walking with sex, household income, and smoking status in mortality (Appendix Figure 2). However, the more apparent interactions were found for household income and smoking status. It appears that the associations with fast walking was more apparent among participants with higher household income and those not currently smoking. No significant variations were seen across race, BMI or comorbidity subgroups.

Among those with fast walking, no further reduction in mortality was found with increasing slow walking time (Table 3). However, among those spending some time slow walking, an increasing amount of fast walking time was found to reduce the mortality further. The association between fast walking time and mortality was independent of LTPA, with no significant interaction observed (Appendix Table 2). For individuals involved in any level of LTPA, regardless of whether they reached the recommended level or not, additional benefits were observed for those who engaged in longer periods of fast walking (HR = 0.84 for > 60 minutes fast walking vs. 0 across all LTPA groups).

Table 3.

Joint associations of daily walking with all-cause and cause-specific mortality, the Southern Community Cohort Study

Slow walking time, minutes Fast walking time, minutes
0 > 0 to 60 > 60
No. of Deaths HR (95%CI) No. of Deaths HR (95%CI) No. of Deaths HR (95%CI)
All causes
  0 1,330 1 (Ref.) 238 0.75 (0.65, 0.86) 667 0.79 (0.72, 0.87)
  > 0 to 120 4,973 0.94 (0.88, 1.00) 2,310 0.79 (0.73, 0.84) 561 0.76 (0.68, 0.84)
  > 120 9,299 0.94 (0.88, 0.99) 3,855 0.78 (0.73, 0.83) 3,629 0.81 (0.76, 0.87)
 CVD
  0 704 1 (Ref.) 111 0.73 (0.59, 0.89) 309 0.79 (0.69, 0.91)
  > 0 to 120 2,667 0.95 (0.87, 1.03) 1,138 0.77 (0.70, 0.85) 258 0.73 (0.63, 0.84)
  > 120 4,796 0.94 (0.86, 1.01) 1,849 0.77 (0.71, 0.84) 1,654 0.77 (0.71, 0.85)
 Cancers
  0 275 1 (Ref.) 70 0.95 (0.73, 1.23) 169 0.85 (0.70, 1.03)
  > 0 to 120 1,111 1.04 (0.91, 1.19) 576 0.89 (0.77, 1.03) 154 0.90 (0.74, 1.10)
  > 120 2,079 0.98 (0.86, 1.11) 989 0.87 (0.76, 1.00) 955 0.92 (0.81, 1.06)
 Other diseases
  0 276 1 (Ref.) 41 0.60 (0.43, 0.83) 128 0.72 (0.58, 0.88)
  > 0 to 120 944 0.85 (0.74, 0.97) 431 0.70 (0.60, 0.82) 104 0.67 (0.53, 0.84)
  > 120 1,954 0.94 (0.83, 1.07) 778 0.75 (0.65, 0.86) 752 0.81 (0.70, 0.93)

Notes: Models were adjusted for enrollment source, age, sex, race, education, marital status, household income, employment, insurance status, smoking status, alcohol intake, diet quality, leisure-time physical activity, daily sitting time, body mass index, and comorbidities. CVD: cardiovascular diseases.

DISCUSSION

In this large prospective cohort study conducted in a predominantly low-income and Black population, regular fast walking was associated with reduced risks of all-cause and major cause-specific mortality. Fast walking was independently associated with reduced mortality, regardless of the levels of LTPA, and engaging in just 15 minutes of fast walking per day resulted in a substantial reduction in the risk of death. These findings highlight the importance of promoting walking, especially fast walking, as a form of physical activity to improve health, particularly in low-income and Black communities where poor health outcomes are prevalent.

To the authors’ knowledge, this is one of the few studies to quantify the effect of daily walking on mortality in a low-income and predominantly Black US population. Historically, these communities have faced barriers to accessing healthcare services. 30,31 By demonstrating the benefits of fast walking, which is a low-cost and largely accessible activity, 32 direct evidence was shown to inform targeted interventions and policies to improve health equity. Public health campaigns and community-based programs can emphasize the importance and availability of fast walking to improve health outcomes, providing resources and support to facilitate increased fast walking within all communities. 33 Furthermore, the findings of the reduced mortality associated with fast walking pace were supported by previous studies conducted in middle and upper-middle income populations. 4,34–36 In this current study, fast walking showed a stronger association with a reduced mortality among higher income participants or those not currently smoking. However, the magnitudes of these associations were generally comparable, and future studies are needed to validate these findings. A faster walking pace was associated with a greater reduction in mortality in a more time-efficient pattern, which suggests that individuals should strive to incorporate more intense physical activity into their routines, such as brisk walking or other forms of aerobic exercise. 5

CVD remains a significant public health concern worldwide, with a substantial impact on morbidity and mortality. 37 Physical activity, including daily walking, is consistently recognized as a modifiable lifestyle factor that can help reduce CVD-specific mortality. 38,39 The findings revealed a strong and significant association between fast walking and CVD-specific mortality, especially for heart diseases. Participants who engaged in fast walking experienced a substantial risk reduction, with as short as a 15-minute walking leading to a 19% lower risk of CVD-specific mortality compared to inactive individuals. The observed benefits of fast walking for a reduction in CVD mortality may be attributed to several underlying mechanisms. First, fast walking is a form of aerobic exercise that improves cardiac output, increases oxygen delivery to the muscles, and enhances the efficiency of the heart’s pumping action. 40 These physiological adaptations contribute to a reduced CVD mortality by improving overall cardiovascular health. Second, fast walking has a positive impact on various CVD risk factors. 41 Regular participation in fast walking helps control body weight and body composition, reducing the prevalence of obesity and its associated cardiovascular risks, such as hypertension and dyslipidemia. Finally, fast walking offers a convenient, accessible, and low-impact activity that individuals of all ages and fitness levels can use to improve cardiovascular health. 42

Long duration of slow walking (>1 hour/day) was significantly associated with reduced mortality due to ischemic heart disease. This finding is supported by previous studies shown that light-intensity walking could have some benefits for cardiometabolic functions. 10 Thus, for individuals unable to walk fast but capable of walking slowly, walking more may still have some benefits.

Limitations

The major strengths of this study are our ability to evaluate potential health benefits by walking pace and the focus on a predominantly low-income and Black population, providing valuable insights into the impact of daily walking on the mortality of an underrepresented population. Long follow-ups and large sample size of this study contributed to robust and reliable estimates. However, some limitations may exist. First, the self-reported data on daily walking may include other types of physical activity for some individuals, such as climbing stairs, which may introduce misclassification. Future studies should consider incorporating objective measurements. Second, information on physical activity was collected only at baseline, limiting the ability to examine the impacts of changes in physical activity over time. Also, reverse causation and unmeasured confounding cannot be ruled out entirely given the nature of observational studies, although the sensitivity analyses showed consistent results. Furthermore, investigating the influence of material well-being and psychosocial stressors on the association between walking and mortality outcomes should be explored in the future, particularly given their high prevalence in low-income populations.

CONCLUSIONS

In a predominantly low-income and Black sample of participants, fast walking was strongly associated with reduced total and cause-specific mortality, underscoring the importance of promoting daily walking as a feasible and effective strategy for improving health outcomes. Public health interventions may prioritize addressing barriers to daily walking, such as inadequate infrastructure, safety concerns, and limited access to recreational spaces, to facilitate increased walking participation among all populations.

Supplementary Material

1

Acknowledgements

The authors thank the study participants and research team members for their contributions to the study, and Rachel Mullen for technical supports in preparing the manuscript.

Funding

Research reported in this publication was supported, in part, by National Institutes of Health under Award Number U01CA202979 and Anne Potter Wilson chair endowment to Vanderbilt University. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Footnotes

Declaration of Interests

The authors declare no conflicts of interest. No financial disclosures have been reported by the authors of this paper.

References:

  • 1.Hakim AA, Petrovitch H, Burchfiel CM, Ross GW, Rodriguez BL, White LR, et al. Effects of walking on mortality among nonsmoking retired men. N Engl J Med. Jan 8 1998;338(2):94–99. doi: 10.1056/nejm199801083380204 [DOI] [PubMed] [Google Scholar]
  • 2.Hanson S, Jones A. Is there evidence that walking groups have health benefits? A systematic review and meta-analysis. Br J Sports Med. Jun 2015;49(11):710–715. doi: 10.1136/bjsports-2014-094157 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 3.Ungvari Z, Fazekas-Pongor V, Csiszar A, Kunutsor SK. The multifaceted benefits of walking for healthy aging: from Blue Zones to molecular mechanisms. Geroscience. Dec 2023;45(6):3211–3239. doi: 10.1007/s11357-023-00873-8 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 4.Stamatakis E, Kelly P, Strain T, Murtagh EM, Ding D, Murphy MH. Self-rated walking pace and all-cause, cardiovascular disease and cancer mortality: individual participant pooled analysis of 50 225 walkers from 11 population British cohorts. Br J Sports Med. Jun 2018;52(12):761–768. doi: 10.1136/bjsports-2017-098677 [DOI] [PubMed] [Google Scholar]
  • 5.Goldney J, Dempsey PC, Henson J, Rowlands A, Bhattacharjee A, Chudasama YV, et al. Self-reported walking pace and 10-year cause-specific mortality: A UK biobank investigation. Prog Cardiovasc Dis. Nov-Dec 2023;81:17–23. doi: 10.1016/j.pcad.2023.09.003 [DOI] [PubMed] [Google Scholar]
  • 6.Saint-Maurice PF, Troiano RP, Bassett DR Jr., Graubard BI, Carlson SA, Shiroma EJ, et al. Association of Daily Step Count and Step Intensity With Mortality Among US Adults. JAMA. Mar 24 2020;323(12):1151–1160. doi: 10.1001/jama.2020.1382 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 7.Banach M, Lewek J, Surma S, Penson PE, Sahebkar A, Martin SS, et al. The association between daily step count and all-cause and cardiovascular mortality: a meta-analysis. Eur J Prev Cardiol. Dec 21 2023;30(18):1975–1985. doi: 10.1093/eurjpc/zwad229 [DOI] [PubMed] [Google Scholar]
  • 8.Inoue K, Tsugawa Y, Mayeda ER, Ritz B. Association of Daily Step Patterns With Mortality in US Adults. JAMA Netw Open. Mar 1 2023;6(3):e235174. doi: 10.1001/jamanetworkopen.2023.5174 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 9.Crespo NC, Mullane SL, Zeigler ZS, Buman MP, Gaesser GA. Effects of Standing and Light-Intensity Walking and Cycling on 24-h Glucose. Med Sci Sports Exerc. Dec 2016;48(12):2503–2511. doi: 10.1249/mss.0000000000001062 [DOI] [PubMed] [Google Scholar]
  • 10.Buffey AJ, Herring MP, Langley CK, Donnelly AE, Carson BP. The Acute Effects of Interrupting Prolonged Sitting Time in Adults with Standing and Light-Intensity Walking on Biomarkers of Cardiometabolic Health in Adults: A Systematic Review and Meta-analysis. Sports Med. Aug 2022;52(8):1765–1787. doi: 10.1007/s40279-022-01649-4 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 11.Safdar NZ, Alobaid AM, Hopkins M, Dempsey PC, Pearson SM, Kietsiriroje N, et al. Short, frequent, light-intensity walking activity improves postprandial vascular-inflammatory biomarkers in people with type 1 diabetes: The SIT-LESS randomized controlled trial. Diabetes Obes Metab. Jun 2024;26(6):2439–2445. doi: 10.1111/dom.15564 [DOI] [PubMed] [Google Scholar]
  • 12.Wongpipit W, Dempsey PC, Zhang X, Poon ET, Darumas N, Miyashita M, et al. Light Walking Patterns and Postprandial Cardiometabolic Responses in Young Obese Adults: A Randomized Crossover Study. J Clin Endocrinol Metab. Nov 11 2024;doi: 10.1210/clinem/dgae789 [DOI] [PubMed] [Google Scholar]
  • 13.Dupré C, Brégère M, Berger M, Pichot V, Celle S, Garet M, et al. Relationship between moderate-to-vigorous, light intensity physical activity and sedentary behavior in a prospective cohort of older French adults: a 18-year follow-up of mortality and cardiovascular events — the PROOF cohort study. Front Public Health. 2023;11:1182552. doi: 10.3389/fpubh.2023.1182552 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 14.Caspi CE, Kawachi I, Subramanian SV, Tucker-Seeley R, Sorensen G. The social environment and walking behavior among low-income housing residents. Soc Sci Med. Mar 2013;80:76–84. doi: 10.1016/j.socscimed.2012.11.030 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 15.Chudyk AM, McKay HA, Winters M, Sims-Gould J, Ashe MC. Neighborhood walkability, physical activity, and walking for transportation: A cross-sectional study of older adults living on low income. BMC Geriatr. Apr 10 2017;17(1):82. doi: 10.1186/s12877-017-0469-5 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 16.Houston D, Basolo V, Yang D. Walkability, transit access, and traffic exposure for low-income residents with subsidized housing. Am J Public Health. Apr 2013;103(4):673–678. doi: 10.2105/ajph.2012.300734 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 17.Zhang YB, Chen C, Pan XF, Guo J, Li Y, Franco OH, et al. Associations of healthy lifestyle and socioeconomic status with mortality and incident cardiovascular disease: two prospective cohort studies. BMJ. Apr 14 2021;373:n604. doi: 10.1136/bmj.n604 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 18.Petrovic D, de Mestral C, Bochud M, Bartley M, Kivimäki M, Vineis P, et al. The contribution of health behaviors to socioeconomic inequalities in health: A systematic review. Prev Med. Aug 2018;113:15–31. doi: 10.1016/j.ypmed.2018.05.003 [DOI] [PubMed] [Google Scholar]
  • 19.Lazar M, Davenport L. Barriers to Health Care Access for Low Income Families: A Review of Literature. J Community Health Nurs. Jan-Mar 2018;35(1):28–37. doi: 10.1080/07370016.2018.1404832 [DOI] [PubMed] [Google Scholar]
  • 20.Himmelstein KEW, Lawrence JA, Jahn JL, Ceasar JN, Morse M, Bassett MT, et al. Association Between Racial Wealth Inequities and Racial Disparities in Longevity Among US Adults and Role of Reparations Payments, 1992 to 2018. JAMA Netw Open. Nov 1 2022;5(11):e2240519. doi: 10.1001/jamanetworkopen.2022.40519 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 21.Signorello LB, Hargreaves MK, Steinwandel MD, Zheng W, Cai Q, Schlundt DG, et al. Southern community cohort study: establishing a cohort to investigate health disparities. J Natl Med Assoc. Jul 2005;97(7):972–979. [PMC free article] [PubMed] [Google Scholar]
  • 22.Buchowski MS, Matthews CE, Cohen SS, Signorello LB, Fowke JH, Hargreaves MK, et al. Evaluation of a questionnaire to assess sedentary and active behaviors in the Southern Community Cohort Study. J Phys Act Health. Aug 2012;9(6):765–775. doi: 10.1123/jpah.9.6.765 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 23.Paluch AE, Bajpai S, Bassett DR, Carnethon MR, Ekelund U, Evenson KR, et al. Daily steps and all-cause mortality: a meta-analysis of 15 international cohorts. Lancet Public Health. Mar 2022;7(3):e219–e228. doi: 10.1016/s2468-2667(21)00302-9 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 24.Arem H, Moore SC, Patel A, Hartge P, Berrington de Gonzalez A, Visvanathan K, et al. Leisure time physical activity and mortality: a detailed pooled analysis of the dose-response relationship. JAMA Intern Med. Jun 2015;175(6):959–967. doi: 10.1001/jamainternmed.2015.0533 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 25.Yu D, Sonderman J, Buchowski MS, McLaughlin JK, Shu XO, Steinwandel M, et al. Healthy Eating and Risks of Total and Cause-Specific Death among Low-Income Populations of African-Americans and Other Adults in the Southeastern United States: A Prospective Cohort Study. PLoS Med. May 2015;12(5):e1001830. doi: 10.1371/journal.pmed.1001830 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 26.Liu L, Wen W, Shrubsole MJ, Lipworth LE, Mumma MT, Ackerly BA, et al. Impacts of Poverty and Lifestyles on Mortality: A Cohort Study in Predominantly Low-Income Americans. Am J Prev Med. Jul 2024;67(1):15–23. doi: 10.1016/j.amepre.2024.02.015 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 27.Vaduganathan M, Mensah GA, Turco JV, Fuster V, Roth GA. The Global Burden of Cardiovascular Diseases and Risk: A Compass for Future Health. J Am Coll Cardiol. Dec 20 2022;80(25):2361–2371. doi: 10.1016/j.jacc.2022.11.005 [DOI] [PubMed] [Google Scholar]
  • 28.Austin PC, Fine JP. Practical recommendations for reporting Fine-Gray model analyses for competing risk data. Stat Med. Nov 30 2017;36(27):4391–4400. doi: 10.1002/sim.7501 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 29.Azur MJ, Stuart EA, Frangakis C, Leaf PJ. Multiple imputation by chained equations: what is it and how does it work? Int J Methods Psychiatr Res. Mar 2011;20(1):40–49. doi: 10.1002/mpr.329 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 30.Connell CL, Wang SC, Crook L, Yadrick K. Barriers to Healthcare Seeking and Provision Among African American Adults in the Rural Mississippi Delta Region: Community and Provider Perspectives. J Community Health. Aug 2019;44(4):636–645. doi: 10.1007/s10900-019-00620-1 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 31.Bantham A, Taverno Ross SE, Sebastião E, Hall G. Overcoming barriers to physical activity in underserved populations. Prog Cardiovasc Dis. Jan-Feb 2021;64:64–71. doi: 10.1016/j.pcad.2020.11.002 [DOI] [PubMed] [Google Scholar]
  • 32.Li M, Li Y, Liu Z, Hystad P, Rangarajan S, Tse LA, et al. Associations of perceived built environment characteristics using NEWS questionnaires with all-cause mortality and major cardiovascular diseases: The prospective urban rural epidemiology (PURE)-China study. Environ Int. Apr 13 2024;187:108627. doi: 10.1016/j.envint.2024.108627 [DOI] [PubMed] [Google Scholar]
  • 33.India-Aldana S, Rundle AG, Zeleniuch-Jacquotte A, Quinn JW, Kim B, Afanasyeva Y, et al. Neighborhood Walkability and Mortality in a Prospective Cohort of Women. Epidemiology. Nov 1 2021;32(6):763–772. doi: 10.1097/ede.0000000000001406 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 34.Dumurgier J, Elbaz A, Ducimetière P, Tavernier B, Alpérovitch A, Tzourio C. Slow walking speed and cardiovascular death in well functioning older adults: prospective cohort study. BMJ. Nov 10 2009;339:b4460. doi: 10.1136/bmj.b4460 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 35.Celis-Morales CA, Gray S, Petermann F, Iliodromiti S, Welsh P, Lyall DM, et al. Walking Pace Is Associated with Lower Risk of All-Cause and Cause-Specific Mortality. Med Sci Sports Exerc. Mar 2019;51(3):472–480. doi: 10.1249/mss.0000000000001795 [DOI] [PubMed] [Google Scholar]
  • 36.Imran TF, Orkaby A, Chen J, Selvaraj S, Driver JA, Gaziano JM, et al. Walking pace is inversely associated with risk of death and cardiovascular disease: The Physicians’ Health Study. Atherosclerosis. Oct 2019;289:51–56. doi: 10.1016/j.atherosclerosis.2019.08.001 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 37.Roth GA, Mensah GA, Johnson CO, Addolorato G, Ammirati E, Baddour LM, et al. Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019: Update From the GBD 2019 Study. J Am Coll Cardiol. Dec 22 2020;76(25):2982–3021. doi: 10.1016/j.jacc.2020.11.010 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 38.Bennett DA, Du H, Clarke R, Guo Y, Yang L, Bian Z, et al. Association of Physical Activity With Risk of Major Cardiovascular Diseases in Chinese Men and Women. JAMA Cardiol. Dec 1 2017;2(12):1349–1358. doi: 10.1001/jamacardio.2017.4069 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 39.Hamer M, O’Donovan G, Stamatakis E. Association between physical activity and sub-types of cardiovascular disease death causes in a general population cohort. Eur J Epidemiol. May 2019;34(5):483–487. doi: 10.1007/s10654-018-0460-2 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 40.Boone-Heinonen J, Evenson KR, Taber DR, Gordon-Larsen P. Walking for prevention of cardiovascular disease in men and women: a systematic review of observational studies. Obes Rev. Mar 2009;10(2):204–217. doi: 10.1111/j.1467-789X.2008.00533.x [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 41.Murtagh EM, Nichols L, Mohammed MA, Holder R, Nevill AM, Murphy MH. The effect of walking on risk factors for cardiovascular disease: an updated systematic review and meta-analysis of randomised control trials. Prev Med. Mar 2015;72:34–43. doi: 10.1016/j.ypmed.2014.12.041 [DOI] [PubMed] [Google Scholar]
  • 42.Omura JD, Ussery EN, Loustalot F, Fulton JE, Carlson SA. Walking as an Opportunity for Cardiovascular Disease Prevention. Prev Chronic Dis. May 30 2019;16:E66. doi: 10.5888/pcd16.180690 [DOI] [PMC free article] [PubMed] [Google Scholar]

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