Table 3.

Patient-related data from retrospective studies. Male (M), female (F), IV (intravenous), primary root Canal treatment (RCT), secondary root Canal treatment (SRCT)

Author/s	Study design	Number and sex of patients	Age	Systemic disease	Systemic treatment	Duration of treatment	Endodontic procedure	Outcome
Hsiao et al., 2009 [17]	Retrospective	28, sex not reported	66,4 (avg)	Osteoporosis	Oral bisphosphonate (alendronate, risedronate, ibandronate)	60 months (avg)	26 RCTs, 8 SRCTs	Healthy
Dereci et al., 2016 [19]	Retrospective	24 (14 F, 10 M)	60,2 (avg)	Metastatic bone disease	IV zoledronate	8 patients for < 1 yr 16 patients for > 1 yr	34 RCTs, 3 SRCTs	Healthy