Figure 3.

Transgenerational increases in ESTR germ-line mutation rate. (a) Mutation rates in the germ line of F₁ and F₂ offspring CBA/H male mice exposed to either 0.4 Gy of fission neutrons or 2 Gy of x-rays. (b) Mutation rates in the germ line of F₁ offspring of CBA/H male mice conceived 3 and 6 weeks after paternal exposure to ionizing radiation and in the germ line of pre- and postmeiotically exposed grandfathers (F₂). Aggregated data for the offspring of male mice exposed to x-rays and fission neutrons are given. The probabilities of difference between mutation rates within each generation are shown (a and b). (c) Comparison of spontaneous mutation rates and transgenerational effects in the germ line of three inbred strains of mice. (d) Individual mutation rates in the germ line of F₁ and F₂ parents of exposed males.