Table 1.
Mutation rates in the germ line of controls and offspring of irradiated males
| Strain, group* | No. of offspring | No. of mutations† | Mutation rate | Ratio to control | Prob.‡ |
|---|---|---|---|---|---|
| CBA/H | |||||
| Control (8♂, 8♀) | 76 | 22 (20) | 0.072 | — | — |
| Neutrons, 0.4 Gy | |||||
| F0, 3 weeks (5♂) | 18 | 1 (1) | 0.028 | 0.4 | 0.55 |
| F0, 6 weeks (5♂) | 43 | 18 (16) | 0.209 | 2.9 | 0.001 |
| F1 (7♂, 9♀) | 83 | 42 (30) | 0.253 | 3.5 | 2.1 × 10−7 |
| F2 (9♂, 7♀) | 84 | 33 (25) | 0.196 | 2.7 | 0.0002 |
| X-rays, 2 Gy | |||||
| F0, 3 weeks (7♂) | 18 | 4 (2) | 0.111 | 1.5 | 0.58 |
| F0, 6 weeks (7♂) | 47 | 18 (16) | 0.192 | 2.6 | 0.003 |
| F1 (13♂, 8♀) | 106 | 47 (39) | 0.222 | 3.1 | 2.1 × 10−6 |
| F2 (13♂, 11♀) | 157 | 75 (57) | 0.239 | 3.3 | 1.2 × 10−8 |
| C57BL/6 | |||||
| Control (4♂, 4♀) | 98 | 25 (21) | 0.064 | — | — |
| Neutrons, 0.4 Gy | |||||
| F0, 6 weeks (3♂) | 45 | 24 (22) | 0.267 | 4.2 | 5.5 × 10−7 |
| F1 (3♂, 5♀) | 58 | 18 (18) | 0.155 | 2.4 | 0.006 |
| F2 (5♂, 5♀) | 63 | 19 (19) | 0.151 | 2.4 | 0.006 |
| BALBc | |||||
| Control (11♂, 12♀) | 94 | 45 (43) | 0.120 | ||
| X-rays, 1 Gy | |||||
| F0, 6 weeks (5♂) | 32 | 18 (16) | 0.281 | 2.4 | 0.003 |
| F1 (5♂, 10♀) | 68 | 42 (36) | 0.309 | 2.6 | 2.7 × 10−6 |
| F2 (8♂, 6♀) | 86 | 43 (35) | 0.250 | 2.1 | 0.0003 |
*
The number of male and female parents is given in parentheses.
†
The number of singleton mutations is given in parentheses.
‡
Prob., probability of difference from the control group (Fisher's exact test, two-tailed).