Table 3.
Reported SDH inhibitors.
| Compound | Microorganism targeted | IC50 | MIC50 or EC50 | Toxicity | Inhibition mechanism |
|---|---|---|---|---|---|
|
| |||||
| Boscalid | Botrytis cinerea | 0.8 μM (Bénit et al. 2019) | 2.7 μM (Wang et al. 2016) | Hepatotoxic, thyrotoxicosis (Federal Register 2025) | QP (Sang and Lee 2020) |
| Fluopyram | Botrytis cinerea | 0.2 μM (Bénit et al. 2019) | 75.6–731 nM (Veloukas and Karaoglanidis 2012) | Hepatotoxic, thyrotoxicosis (Federal Register, 2019) | QP (Sang and Lee 2020) |
| Bixafen | Rhinzoctonia solani | 3 μM (Zhang A et al. 2019) | 104 nM (Zhang A et al. 2019) | Hepatotoxic, thyrotoxicosis (solely in the presence of the former) (Federal Register 2018) | QP (Sang and Lee 2020) |
| Promysalin | P. aeruginosa | 2.5 μM (Keohane et al. 2018) | 1.8 μM (Li W et al. 2011) | Ubiquinone-binding site | |
| Siccanin | P. aeruginosa | 0.9 μM (Mogi et al. 2009) | 150 μM (Mogi et al. 2009) | DLD-1 EC50 34 μM HDF EC50 16 μM (Komatsuya et al. 2022) | Ubiquinone-binding site |
| Siccanin | P. falciparum | 16 nM and 8.9 μM (biphasic) (Komatsuya et al. 2022) | 8.4 μM (Komatsuya et al. 2022) | DLD-1 EC50 34 μM HDF EC50 16 μM (Komatsuya et al. 2022) | Ubiquinone-binding site |