Table 4.

Prognostic markers in cardiac amyloidosis imaging

Modality	Prognostic markers
Echocardiography	Apical sparing pattern: suggests better preserved function Reduced RV free wall strain: predicts worse outcomes Myocardial work indices and GLS dispersion: associated with adverse prognosis
SPECT/CT	High myocardial SUVmax or retention index: associated with worse outcomes RV uptake: linked to greater disease burden and mortality Correlates with ECV and LV mass on CMR
CMR	Elevated ECV: associated with reduced survival Prolonged T2 relaxation time: independent predictor of mortality High native T1 values: associated with poor outcome Reduced GLS and LA strain: predictive of MACE

ATTR, transthyretin amyloidosis; AL, light-chain amyloidosis; SPECT/CT, single-photon emission computed tomography/computed tomography; CMR, cardiovascular magnetic resonance; ECV, extracellular volume; T1/T2, MRI relaxation times; SUV, standardized uptake value; SUVmax, maximum standardized uptake value; GLS, global longitudinal strain; LA, left atrial; MACE, major adverse cardiovascular events; LV, left ventricle; RV, right ventricle