Skip to main content
. 2002 May 14;99(10):6943–6948. doi: 10.1073/pnas.052143799

Figure 2.

Figure 2

Sterol regulation of StarD4 expression. (A) Regulation by dietary cholesterol in mouse liver. C57BL/6 female mice were fed a semisynthetic diet with no cholesterol (0.00%, n = 5) or the same diet supplemented to 0.50% cholesterol (n = 5). StarD4 expression was measured in each liver by quantitative RT-PCR. (B and C) Regulation by sterols in cultured 3T3 cells. 3T3-L1 cells were cultured in one of three media: control, sterols, or statin (n = 4 wells each, see Materials and Methods). Expression of StarD4, hydroxymethylglutaryl-CoA reductase (HMGR) and synthase (HMGS), low density lipoprotein receptor (LDLR), and ATP:citrate lyase (ACLY) was measured in each well. All data (mean ± SD) are normalized to cyclophilin and control condition set equal to 100% for each gene. *, P < 0.001 vs. control, **, P < 0.05 vs. control.