Table 1.

Splenic amyloid deposits in mice treated with AEF i.v. and AgNO₃ s.c. compared with controls treated with H₂O i.v. and AgNO₃ s.c., killed on day 16

AEF dose per mouse, μg	Incidence of mice with amyloid	Amyloid grade
4	3/3	4+
2	3/3	4+
1	3/3	4+
0.5	3/3	4+
0.25	3/3	4+
0.125	3/3	4+
0.0625	3/3	4+
0.03125	3/3	4+
0.01562	3/3	4+
0.00781	3/3	4+
0.0039	5/5	4+
0.00195	3/3*	4+
0.000976	5/5	3+ to 4+
0.000488	5/5	2+ to 4+
0.000244	5/5	2+ to 3+
0.000122	5/5	1+ to 2+
0.000061	2/5	1+
0.000030	4/4†	1+ to 3+
0.000015	2/5	1+
0.000008	0/5	–
0	0	–

^*Two mice died at the beginning of the experiment. 

^† One mouse died at the beginning of the experiment.