Table 3.

Splenic amyloid deposits induced by i.v. treatment with AEF and AgNO₃ injected s.c. 0–125 days after AEF administration, as compared with controls treated with H₂O i.v. and AgNO₃ s.c.

Time delay, days	Duration of experiment after first AgNO3 injection
	AEF						H2O
	2 days		8 days		16 days		16 days
	Incidence of mice with amyloid	Amyloid grade	Incidence of mice with amyloid	Amyloid grade	Incidence of mice with amyloid	Amyloid grade	Incidence of mice with amyloid	Amyloid grade
0	2/2	2+	2/2	3+	2/2	4+	0/2	–
2	2/2	2+ to 3+	2/2	3+	2/2	4+	0/2	–
4	2/2	1+	2/2	1+	2/2	4+	0/2	–
8	2/2	1+ to 3+	2/2	3+ to 4+	2/2	4+	0/2	–
16	2/2	1+	2/2	2+ to 4+	2/2	4+	0/2	–
25	2/2	1+	2/2	1+	2/2	4+	0/2	–
50	4/4	1+ to 3+	2/2	3+	4/4	4+	0/4	–
75	2/2	3+ to 4+	–	–	2/2	4+	0/2	–
125	2/2	1+ to 2+	–	–	2/2	4+	0/2	–