Skip to main content
. 2025 Sep 12;20(1):20251252. doi: 10.1515/med-2025-1252

Figure 5.

Figure 5

Heterozygous ATG7+/− rats enhanced OTM in the orthodontic model. (a) Rats were identified by performing PCR. (b) and (c) Micro-CT scan and analysis. The results of tooth movement data are expressed as mean ± SD; the wild-type group was 0.193 ± 0.01 mm, and the ATG7+/− group was 0.295 ± 0.04 mm. (d) and (e) Immunohistochemistry staining and its quantitative analysis for autophagy proteins, RANKL, and OPG. The autophagy-related proteins in the ATG7+/− group were lower when compared to the wild-type group on the compression side, but with a significantly increased RANKL/OPG expression. n = 3 per group; samples were selected based on the technical quality for histological analysis. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.