Table 3.
Calendar Time Trends in the Prevalence of Chronic Non-AIDS Conditions Among Hospitalized Persons With HIV in 5 Cohorts of the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD), 2008–2018
| Unadjusted Prevalence (95% CI) |
Relative Change per Year (95% CI) |
|||
|---|---|---|---|---|
| Condition | 2008 | 2018 | Adjusted for NA-ACCORD Cohorta | Adjusted for Age and Cohortb |
|
| ||||
| HBV infection | 6.3% (4.8%, 7.7%) | 6.3% (4.8%, 7.8%) | 1.2% (−1.5%, 3.9%) | 1.6% (−1.1%, 4.3%) |
| HCV infection | 28.0% (25.2%, 30.7%) | 20.7% (18.2%, 23.1%) | −0.8% (−1.9%, 0.2%) | −2.0% (−3.0%, −0.9%) |
| Hypertension | 38.4% (35.4%, 41.3%) | 49.6% (46.6%, 52.6%) | 2.8% (2.1%, 3.5%) | 0.4% (−0.2%, 1.1%) |
| Hyperlipidemia | 20.5% (18.0%, 22.9%) | 38.7% (35.7%, 41.6%) | 6.7% (5.5%, 7.8%) | 3.6% (2.5%, 4.7%) |
| Diabetes mellitus | 12.5% (10.5%, 14.6%) | 20.8% (18.3%, 23.2%) | 6.1% (4.5%, 7.7%) | 2.8% (1.3%, 4.4%) |
| CKD stage ≥3 | 11.7% (9.8%, 13.7%) | 21.0% (18.5%, 23.4%) | 7.4% (5.7%, 9.1%) | 3.3% (1.7%, 4.9%) |
| Two or more conditions | 33.2% (30.3%, 36.1%) | 46.1% (43.1%, 49.1%) | 4.0% (3.2%, 4.8%) | 1.3% (0.6%, 2.0%) |
| Three or more conditions | 15.9% (13.7%, 18.2%) | 27.9% (25.2%, 30.6%) | 6.7% (5.3%, 8.1%) | 3.0% (1.7%, 4.3%) |
Abbreviations: CKD, chronic kidney disease; HBV, hepatitis B virus; HCV, hepatitis C virus; HIV, human immunodeficiency virus.
Estimates and 95% CIs were obtained from separate log-binomial regression models, including only NA-ACCORD cohort as a covariate, with generalized estimating equations to account for patients contributing to more than 1 calendar year of analysis.
Estimates and 95% CIs were obtained from separate log-binomial regression models, including age (categorized as <42, 42–49, 50–57, and ≥58 y) and NA-ACCORD cohort as covariates, with generalized estimating equations.