Figure 1.

Organization of serotype 1 MDV viral genome. (A) The MDV genome consists of a unique long (U_L) region flanked by inverted repeats, terminal repeat long (TR_L), internal repeat long (IR_L), and a unique short region (U_S) also flanked by two inverted repeats, internal repeat short (IR_S) and terminal repeat short (TR_S). (B) Schematic representation of the overlapping clones generated to reconstitute an infectious virus from a very virulent (vv) strain of MDV (Md5). The restriction enzymes used to generate the cosmid clones and their positions are indicated. (C) Location of EcoRI restriction sites in cosmid A6 used to delete the MDV-specific pp38 gene.