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. Author manuscript; available in PMC: 2025 Sep 23.
Published before final editing as: Annu Rev Genet. 2025 Aug 19:10.1146/annurev-genet-020325-095743. doi: 10.1146/annurev-genet-020325-095743

Figure 4.

Figure 4

Differential expression of globin genes by changes in interactions with the LCR.

In these conceptual illustrations, interaction with a transcriptionally active zone (hub, factory, biomolecular condensate, portrayed as a yellow-orange oval) anchored on the LCR leads to expression of a globin gene. Shifts in the genes interacting with the LCR active zone in erythroid cells at progressive stages of development result in differential expression. Shades of brown indicate repression. These different interactions are shown as occurring with the subTAD containing the LCR and globin genes. Similar shifts in patterns of interaction of genes with the LCR are indicated for both the HBB and HBA gene clusters. No information is currently available LCR-gene interactions for the HBB locus in embryonic primitive erythroblasts, indicated by the dashed outline around the illustration. Abbreviations: BG = BGLT3, P1 = HBBP1.