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. 2025 Aug 4;6(3):e600. doi: 10.1097/AS9.0000000000000600

TABLE 2.

Pros and Cons of Various Surgical Glove Materials

Latex Nitrile Neoprene Polyisoprene
Structure Cis-IP natural rubber Acrylonitrile butadiene Chloroprene Cis-IP synthetic rubber
 Pros Fit and tactile sensitivity Hypoallergenic; chemical resistance, durability, and puncture resistance Chemical resistance, temperature resistance, and durability Similar fit and feel of natural rubber latex without the risk of latex allergy
 Cons Risk of allergic reactions to latex proteins Generally considered to be stiffer than latex of polyisoprene alternatives Some users feel that they are stiffer than their latex or polyisoprene alternatives Significantly more expensive than the alternatives