Table 2.
Comparison of clinical features of T2DM patients with different HOMA-IR scores [M (Q3–Q1)].
| Characteristics | T2DM (n=779) | χ2/F/Z | P | ||
|---|---|---|---|---|---|
| IS (n=385) | EIR (n=170) | SIR (n=224) | |||
| Male, n (%) | 262 (68.05%) | 117 (68.82%) | 154 (68.75%) | 0.048 | 0.976 |
| Age (years) | 56 (46.50,62.00) | 56 (46.00,65.00) | 55 (44.00,63.00) | 2.631 | 0.268 |
| BMI (kg/m2) | 24.14 (21.60, 27.67) | 24.35 (21.58,27.80) | 24.43 (21.65, 28.25) | 1.733 | 0.178 |
| Smoking, n (%) | 156 (40.52%) | 70 (41.18%) | 91 (40.63%) | 0.022 | 0.989 |
| Drinking, n (%) | 63 (16.36%) | 26 (15.29%) | 35 (15.63%) | 0.121 | 0.941 |
| Blood routine examination | |||||
| WBC (×109/L) | 5.79 (4.69,6.93) | 5.77 (4.88,6.81) | 6.25 (5.32,7.61)ab | 19.380 | 0.000 |
| MONO (×109/L) | 0.34 (0.29,0.45) | 0.37 (0.30,0.45) | 0.39 (0.31,0.48) a | 9.841 | 0.007 |
| LYMP (×109/L) | 1.72 (1.39,2.11) | 1.64 (1.42,2.06) | 1.52 (1.28,1.92)ab | 19.054 | 0.000 |
| NEUT (×109/L) | 3.40 (2.70,4.32) | 3.51 (2.86,4.45) a | 3.82 (2.96,4.79)ab | 16.044 | 0.000 |
| PLT (×109/L) | 204 (177.5,231) | 213.5 (185,241) a | 234.5 (196.25,265.00)ab | 46.656 | 0.000 |
| Biochemical indicators | |||||
| LDL-C (mmol/L) | 2.48 (1.81,3.06) | 2.67 (1.90,3.26) a | 2.72 (2.07,3.41) b | 8.614 | 0.013 |
| HDL-C (mmol/L) | 1.09 (0.88,1.32) | 0.96 (0.80,1.14) a | 0.95 (0.82,1.11) a | 40.985 | 0.000 |
| TG (mmol/L) | 1.26 (0.96,1.98) | 1.84 (1.31,2.71) a | 1.91 (1.38,3.00) a | 74.477 | 0.000 |
| TC (mmol/L) | 4.69 (3.81,5.49) | 4.51 (3.73,5.31) | 4.77 (4.07,5.74) b | 4.498 | 0.106 |
| SUA (×109/L) | 311.00 (259.00,375.95) | 355.45 (319.63,400.93) a | 396.45 (344.68,452.15)ab | 123.845 | 0.000 |
| fasting C-peptide | 0.87 (0.52,1.12) | 1.59 (1.21,1.88) a | 2.26 (1.72,2.94)ab | 433.702 | 0.000 |
| fasting insulin | 3.00 (1.81,4.26) | 7.00 (5.19,8.34) a | 11.28 (8.75,15.27)ab | 536.771 | 0.000 |
| Glucose (mmol/L) | 7.24 (5.86,9.47) | 7.62 (6.14,9.74) | 8.27 (6.83,10.87)ab | 24.116 | 0.000 |
| Inflammatory index | |||||
| SII | 392.41 (302.84,545.09) | 428.05 (331.34,598.32) a | 561.95 (422.78,776.83)ab | 66.152 | 0.000 |
| SIRI | 0.68 (0.49,1.02) | 0.75 (0.55,1.05) | 0.95 (0.61,1.36)ab | 39.306 | 0.000 |
| MHR | 0.34 (0.23,0.45) | 0.40 (0.30,0.51) a | 0.40 (0.29,0.57) a | 32.923 | 0.000 |
| UHR | 283.74 (204.38,388.59) | 376.30 (294.77,461.87) a | 412.19 (323.44,500.22)ab | 110.592 | 0.000 |
Data are expressed as n (%) for categorical variables and as M (Q3-Q1) for continuous variables with non-normal distribution. M (Q3-Q1), median (interquartile range); BMI, Body mass index; WBC, White blood cell; MONO, Monocyte; LYMP, Lymphocyte; PLT, Platelet; NEUT, Neutrophil; TC, Total cholesterol; LDL-C, Low-density lipoprotein cholesterol; TG, Triglyceride; HDL-C, High density lipoprotein cholesterol; SUA, serum uric acid; SII, systemic immune-inflammation index; SIRI, systemic inflammation response index; MHR, monocyte-to-high-density lipoprotein ratio; UHR, serum uric acid to HDL-C ratio. P<0.05 was considered statistically significant.
P<0.05 compared to the IS group.
P<0.05 compared the EIR group.
P values shown in bold indicate that the statistical analysis is significant.