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. 2025 Sep 9;16:1648823. doi: 10.3389/fendo.2025.1648823

Table 5.

ROC curve analysis for the degree of IR in T2DM.

Group Indicators Sensitivity (%) Specificity (%) Cut-off point AUC 95% CI P
IS SII 73.53 32.44 567.88 0.513 0.464-0.561 0.614
SIRI 76.49 30.34 0.93 0.510 0.462-0.558 0.683
MHR 79.42 34.03 0.29 0.550 0.504-0.596 0.045
UHR 92.93 25.49 241.14 0.593 0.549-.637 0.000
Comebine 92.94 25.54 0.18 0.593 0.549-0.637 0.000
EIR SII 57.41 66.00 421.58 0.638 0.599-0.677 0.000
SIRI 66.24 50.32 0.87 0.606 0.567-0.646 0.004
MHR 37.73 80.54 0.28 0.617 0.577-0.656 0.000
UHR 52.74 81.72 289.58 0.714 0.677-0.750 0.000
Comebine 58.73 79.24 1.74 0.740 0.705-0.774 0.000
SIR SII 70.50 60.44 448.93 0.679 0.638-0.720 0.000
SIRI 57.62 63.21 0.85 0.638 0.595-0.681 0.000
MHR 34.41 83.12 0.52 0.600 0.556-0.644 0.000
UHR 48.33 80.81 309.22 0.684 0.646-0.723 0.000
Comebine 58.03 76.63 0.31 0.733 0.696-0.770 0.000

SII is the systemic immune-inflammation index; SIRI is the systemic inflammation response index; MHR is the ratio of monocytes to high-density lipoprotein cholesterol. UHR is the ratio of serum uric acid to high-density lipoprotein cholesterol.