Table 4.

Validation metrics in sensitivity analysis.

Metric	ACC/AHA ASCVD function (optimal threshold, 8.2%)	2008 FHS global CVD function (optimal threshold, 13.6%)
Sensitivity	54.0% (95% CI, 35.5%-71.4%)	53.3% (95% CI, 34.8%-71.0%)
Specificity	50.9% (95% CI, 38.2%-63.8%)	56.4% (95% CI, 43.4%-69.3%)
PPV	37.2% (95% CI, 22.0%-53.2%)	40.0% (95% CI, 25.5%-56.7%)
NPV	66.6% (95% CI, 52.3%-80.5%)	68.9% (95% CI, 54.5%-82.6%)

ACC/AHA, American College of Cardiology/American Heart Association; ASCVD, atherosclerotic cardiovascular disease; FHS, Framingham Heart Study; CI, confidence interval; CVD, cardiovascular disease risk calculator; NPV, negative predictive value; PPV, positive predictive value.