Table 1.
Clinical and laboratory characteristics of mild to moderate bleeding disorder patients overall and according to diagnoses, and of healthy controls.
Cohort | MBD | BDUC | PFD | VWD | CFD | HC |
---|---|---|---|---|---|---|
Cohort size, n (%) | 646 (100) | 432 (67) | 133 (21) | 63 (10) | 18 (2) | 118 (100) |
White ethnicity, n (%) | 633 (99) | 426 (99) | 126 (95) | 63 (100) | 18 (100) | 118 (100) |
Women, n (%) | 540 (84) | 371 (86) | 109 (82) | 54 (86) | 6 (33) | 94 (80) |
Blood group Oa, n (%) | 305 (48) | 191 (45) | 59 (45) | 46 (73) | 9 (50) | 17 (40) |
Age (y), median (IQR) | 40 (29-53) | 41 (30-54) | 37 (27-53) | 33 (25-44) | 45 (25-57) | 46 (31-52) |
BMI (kg/m2), median (IQR) | 23 (21-27) | 23 (21-27) | 23 (20-26) | 23 (20-26) | 25 (23-29) | 23 (21-25) |
Vicenza BS, median (IQR) | 5 (4-8) | 5 (4-8) | 5 (3-8) | 5 (4-8) | 5 (4-9) | 0 (0-0) |
No. of bleeding manifestations, median (IQR) | 6 (4-7) | 5 (4-7) | 6 (4-7) | 6 (5-8) | 7 (6-9) | 0 (0-0) |
Hemoglobin (g/dL), mean (SD) | 13.6 (1.3) | 13.6 (1.2) | 13.7 (1.3) | 13.5 (1.4) | 13.7 (2.0) | 13.7 (1.2) |
MCV (fL), mean (SD) | 87.4 (4.5) | 87.5 (4.5) | 87.6 (4.6) | 86.4 (4.6) | 87.3 (3.2) | 87.2 (4.2) |
MCH (pg), mean (SD) | 29.4 (1.8) | 29.5 (1.8) | 29.4 (1.9) | 29.1 (1.9) | 29.9 (1.2) | 29.7 (1.8) |
Platelet count (G/L), mean (SD) | 251 (65) | 251 (59) | 244 (61) | 271 (98) | 245 (85) | 261 (47) |
Ferritin (μg/L), median (IQR) | 49.9 (27.1-106.1) | 50.3 (27.2-106.1) | 61.9 (31.3-117.0) | 31.2 (21.3-53.1) | 92.6 (36.6-123.8) | 54.2 (28.7-101.1) |
Transferrin saturation (%), mean (SD) | 24.4 (11.4) | 24.1 (10.8) | 24.0 (10.6) | 27.6 (16.7) | 24.2 (8.6) | 25.4 (10.9) |
BDUC, bleeding disorder of unknown cause; BMI, body mass index; BS, Bleeding Score; CFD, coagulation factor deficiency; HC, healthy control; MBD, mild to moderate bleeding disorder; MCH, mean corpuscular hemoglobin; MCV, mean corpuscular volume; PFD, platelet function disorder; VWD, von Willebrand disease.
Blood group analysis was available for 640 patients with MBD (99%) and 42 HC (36%).