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. 2025 Aug 11;9(6):102999. doi: 10.1016/j.rpth.2025.102999

Table 1.

Clinical and laboratory characteristics of mild to moderate bleeding disorder patients overall and according to diagnoses, and of healthy controls.

Cohort MBD BDUC PFD VWD CFD HC
Cohort size, n (%) 646 (100) 432 (67) 133 (21) 63 (10) 18 (2) 118 (100)
White ethnicity, n (%) 633 (99) 426 (99) 126 (95) 63 (100) 18 (100) 118 (100)
Women, n (%) 540 (84) 371 (86) 109 (82) 54 (86) 6 (33) 94 (80)
Blood group Oa, n (%) 305 (48) 191 (45) 59 (45) 46 (73) 9 (50) 17 (40)
Age (y), median (IQR) 40 (29-53) 41 (30-54) 37 (27-53) 33 (25-44) 45 (25-57) 46 (31-52)
BMI (kg/m2), median (IQR) 23 (21-27) 23 (21-27) 23 (20-26) 23 (20-26) 25 (23-29) 23 (21-25)
Vicenza BS, median (IQR) 5 (4-8) 5 (4-8) 5 (3-8) 5 (4-8) 5 (4-9) 0 (0-0)
No. of bleeding manifestations, median (IQR) 6 (4-7) 5 (4-7) 6 (4-7) 6 (5-8) 7 (6-9) 0 (0-0)
Hemoglobin (g/dL), mean (SD) 13.6 (1.3) 13.6 (1.2) 13.7 (1.3) 13.5 (1.4) 13.7 (2.0) 13.7 (1.2)
MCV (fL), mean (SD) 87.4 (4.5) 87.5 (4.5) 87.6 (4.6) 86.4 (4.6) 87.3 (3.2) 87.2 (4.2)
MCH (pg), mean (SD) 29.4 (1.8) 29.5 (1.8) 29.4 (1.9) 29.1 (1.9) 29.9 (1.2) 29.7 (1.8)
Platelet count (G/L), mean (SD) 251 (65) 251 (59) 244 (61) 271 (98) 245 (85) 261 (47)
Ferritin (μg/L), median (IQR) 49.9 (27.1-106.1) 50.3 (27.2-106.1) 61.9 (31.3-117.0) 31.2 (21.3-53.1) 92.6 (36.6-123.8) 54.2 (28.7-101.1)
Transferrin saturation (%), mean (SD) 24.4 (11.4) 24.1 (10.8) 24.0 (10.6) 27.6 (16.7) 24.2 (8.6) 25.4 (10.9)

BDUC, bleeding disorder of unknown cause; BMI, body mass index; BS, Bleeding Score; CFD, coagulation factor deficiency; HC, healthy control; MBD, mild to moderate bleeding disorder; MCH, mean corpuscular hemoglobin; MCV, mean corpuscular volume; PFD, platelet function disorder; VWD, von Willebrand disease.

a

Blood group analysis was available for 640 patients with MBD (99%) and 42 HC (36%).