Table 2.
Prevalence of iron deficiency and iron deficiency anemia in patients with mild to moderate bleeding disorder overall and according to mild to moderate bleeding disorder diagnoses, and for healthy controls.
| Iron status in MBD |
MBD |
BDUC |
PFD |
VWD |
CFD |
HC |
|---|---|---|---|---|---|---|
| Total cohort | n = 646 | n = 432 | n = 133 | n = 63 | n = 18 | n = 118 |
| ID, n (%) | 250 (38.7) | 170 (39.4) | 44 (33.1) | 31 (49.2) | 5 (27.8) | 37 (31.4) |
| P value vs HC | .13 | .11 | .77 | .018a | .76 | |
| IDA, n (%) | 40 (6.2) | 25 (5.8) | 9 (6.8) | 6 (9.5) | 0 (0) | 6 (5.1) |
| P value vs HC | .64 | .769 | .575 | .347 | 1.0 |
| Iron status in MBD |
MBD |
BDUC |
PFD |
VWD |
CFD |
HC |
|---|---|---|---|---|---|---|
| Women < 55 y | n = 428 (79%) | n = 286 (77%) | n = 85 (78%) | n = 28 (52%) | n = 6 (100%) | n = 72 (77%) |
| ID, n (%) | 205 (48.0) | 142 (49.7) | 33 (38.8) | 28 (54.9) | 2 (33.3) | 29 (40.3) |
| P value vs HC | .23 | .155 | .85 | .109 | 1.0 | |
| IDA, n (%) | 31 (7.2) | 20 (7.0) | 6 (7.0) | 5 (9.8) | 0 (0) | 6 (8.3) |
| P value vs HC | .74 | .695 | .765 | .76 | 1.0 |
The reported P values are the results of chi-squared tests and Fisher’s exact tests comparing the respective MBD diagnosis with healthy controls. The overall comparisons (HC/BDUC/PFD/VWD/CFD) using the chi-squared test were not statistically significant (total cohort: ID: P = .09; IDA: P = .579; women < 55 years: ID: P = .19; IDA: P = .897).
BDUC, bleeding disorder of unknown cause; CFD, coagulation factor deficiency; HC, healthy control; ID, iron deficiency; IDA, iron deficiency anemia; MBD, mild to moderate bleeding disorder; PFD, platelet function defect; VWD, von Willebrand disease.
Significance did not prevail after correction for multiple testing using the Bonferroni–Holm method.