Table 4.
Associations of bleeding symptoms with iron deficiency in patients with mild to moderate bleeding disorders.
| Symptom | n (%) | ID, n (%) | P valuee | |
|---|---|---|---|---|
| HMBa | HMB | 353 (66) | 155 (44) | .44 |
| No HMB | 183 (34) | 74 (40) | ||
| PPHb | PPH | 122 (37) | 53 (43) | .08 |
| No PPH | 210 (63) | 71 (34) | ||
| Hematomas/easy bruising | Hematomas | 442 (69) | 182 (41) | .06 |
| No hematomas | 203 (31) | 68 (34) | ||
| Intraarticular bleeding | Intraarticular bleeding | 22 (3) | 9 (41) | .826 |
| No intraarticular bleeding | 622 (97) | 240 (39) | ||
| Prolonged wound bleeding | Prolonged wound bleeding | 241 (37) | 95 (39) | .828 |
| No prolonged wound bleeding | 402 (63) | 155 (39) | ||
| Bleeding after TEc | Post-TE bleeding | 214 (38) | 84 (39) | .78 |
| No post-TE bleeding | 344 (62) | 131 (38) | ||
| Epistaxis | Epistaxis | 227 (35) | 87 (38) | .886 |
| No epistaxis | 419 (65) | 163 (39) | ||
| Oral/mucosal bleeding | Oral bleeding | 187 (29) | 71 (38) | .84 |
| No oral bleeding | 456 (71) | 177 (39) | ||
| GI bleeding | GI bleeding | 87 (13) | 31 (36) | .52 |
| No GI bleeding | 558 (87) | 219 (39) | ||
| Postsurgical bleedingc | Postsurgical bleeding | 348 (59) | 111 (32) | <.001d |
| No postsurgical bleeding | 239 (41) | 111 (46) | ||
| Intramuscular bleeding | Intramuscular bleeding | 16 (2) | 5 (31) | .54 |
| No intramuscular bleeding | 627 (98) | 243 (39) |
GI, gastrointestinal; HMB, heavy menstrual bleeding; ID, iron deficiency; PPB, postpartum bleeding; PPH, postpartum hemorrhage; TE, tooth extraction.
a
Only including female patients with mild to moderate bleeding disorders.
b
Only including female patients with mild to moderate bleeding disorders who delivered a child (excluding cesarean section) prior to study inclusion.
c
Only including patients who had undergone surgery or TE prior to study inclusion.
d
Significance prevailed after Bonferroni–Holm correction for multiple testing.
e
Chi-squared test.