Table 2.
Characteristics of the included studies investigating the prognostic value of PDW
| Author (year) | Location | Population | Condition | Mean age (Mean [SD]) | Male percentage | Study design | Follow-up period | PDW (Mean [SD]) | Outcome | Measure effect |
|---|---|---|---|---|---|---|---|---|---|---|
| Marques et al. (2023) | Portugal | 394 | Acute HF | 79.1 (9.4) | 38.1 | Retrospective cohort | One year | 13.7 (0.6) | All-cause mortality and rehospitalization | Multivariable Fine and Gray model for rehospitalization (event of interest) and death without rehospitalization (competing event) due to AHF: Rehospitalization: HR of (1.02 [0.95-1.1]) |
| Mortality: HR of (0.89 [0.81-0.97]) | ||||||||||
| Marques et al. (2023) | Portugal | 429 | Acute HF | 79 (10) | 37.5 | Retrospective cohort | One year | 13.7 (2.6) | All-cause mortality | Multivariable logistic regression: OR of 0.88 (0.80-0.97) |
| Sato et al. (2022) | Japan | 400 | HF patients with CHD | 34 (16) | 49 | Retrospective | Three years | NA | HF-related hospitalization and thrombus formation | Multivariate logistic regression (OR for hospitalization: 1.36 [1.05-1.76] and OR for thrombus formation: 1.99 [1.46-2.63]) |
| Multivariate Cox regression (HR for hospitalization: 3.74 [2.19-6.77] and HR for thrombus formation: 9.17 [3.65-30.7]) | ||||||||||
| Zhang et al. (2019) | China | 336 | HF | 62.33 (10.6) | 56 | cross-sectional | One year | 16.30 (2.07) | Renal dysfunction | Logistic regression: OR of 0.65 (0.47-0.88) |
| Sato et al. (2020) | Japan | 1746 | HF | 68.67 (14.7) | 59.6 | Prospective cohort | Ten years | 15.98 (1.14) | All-cause death, | Multivariate Cox regression: HR for all-cause death 1.04 (1-1.09); HR for cardiac death 1.08 (1.02-1.15) |
| cardiac death, | ||||||||||
| CVD events | ||||||||||
| Siedlecki et al. (2019) | Poland | 367 | HF + DM | 62.6 (11.6) | 75.7 | Retrospective cohort | Four years | 13.45 (1.96) | All-cause death | Univariate Cox proportional hazard regression analysis: HR of 0.94 [0.88-1.01] |
| Ishino et al. (2018) | Japan | 205 | CHF | NA | NA | Prospective cohort | Two years | 15.8 (0.6) | CVD events and mortality | Multivariate Cox proportional hazard analysis: HR of 1.576, P-value <0.05 |
| Lelli et al. (2022) | Italy | 415 | HFpEF, HFmrEF, and HFrEF | 83.1 (7) | 171 (41%) | Cross-sectional | NA | 13.3 (2.7) | NT-proBNP level | Significant correlation between NT-proBNP and MPV level (r=0.09, P=0.04) which was confirmed by multivariate linear regression (P=0.004) |
Abbreviations: CVD, cardiovascular; HR, hazard ratio; OR, odds ratio; NA, not available; AHF, acute heart failure; HFrEF, heart failure with reduced ejection fraction; HFpEF, heart failure with preserved ejection fraction; HFmrEF, heart failure with mid-range ejection fraction; CHD, congenital heart disease; DM, diabetes mellitus; CHF, congestive heart failure; NT-proBNP, N-terminal prohormone of brain natriuretic peptide.