. 2025 Aug 15;15(4):96–101. doi: 10.62347/GCUG1405

Table 1.

Acute Erythroid Leukemia cases reported in pediatric population

Cases	Age/Sex	Presentation	HB/ANC/Platelet	PBS findings	BMA findings	FCMI	Karyotype	Follow up
Case 1	16 yrs/F	Fever, severe fatigue and mucocutaneous bleeding	7.8 g/dL/0.468×10⁹/L/67×10⁹/L	5% myeloblasts, 12% erythroblasts	93% erythroblasts with >30% proerythroblasts	Positive for CD4 (33%), CD13 (46.2%), CD33 (63.3%), CD71 (42%), glycophorin A (27%), HLA-DR (56.4%), and negative for other myeloid and lymphoid markers	N/A	Died 3 days of starting the induction chemotherapy (Daunorubicin andcytarabine)
Ouahidi et al [5].	16 yrs/F	Fever, severe fatigue and mucocutaneous bleeding	7.8 g/dL/0.468×10⁹/L/67×10⁹/L	5% myeloblasts, 12% erythroblasts	93% erythroblasts with >30% proerythroblasts		N/A
Case 2	5 yrs/M	Pain in leg, fever, gingival hypertrophy	6 g/dL/leukocytes and platelets normal in number	Anaemia	85% erythroblasts	Positive for CD71, CD235a, HLA DR, CD45, CD38, CD13 and negative for CD41, CD4, CD34, CD14	46 XY (Normal)	N/A
Abrantes et al [6].	5 yrs/M	Pain in leg, fever, gingival hypertrophy	6 g/dL/leukocytes and platelets normal in number	Anaemia	85% erythroblasts		46 XY (Normal)	N/A
Case 3	1 yrs/M	Fever, pallor, bleeding gums, bruising, splenomegaly	8.2 g/dL/3.62×10⁹/L/8×10⁹/L	Anemia, erythroblast predominance, leukocytosis severe thrombocytopenia	74% Erythroblasts with 50% proethroblasts and 10% myeloblasts	N/A	N/A	Died at 16^th day of starting induction chemotherapy
Prabawa et al [7].	1 yrs/M	Fever, pallor, bleeding gums, bruising, splenomegaly	8.2 g/dL/3.62×10⁹/L/8×10⁹/L			N/A	N/A	Died at 16^th day of starting induction chemotherapy
Case 4	4 mos/F	Pallor, wheezing, irritability, Flu like symptoms, hepatosplenomegaly	5.4 g/dL/leukocytes normal in number/86×10⁹/L	N/A	75% Erythroblasts	Positive for CD71, CD235a	Complex 48, XX, +8, +22 [12] 48, idem, del (10)(q23) [7]/46,XX [7]	Died 8 months after diagnosis (Daunorubicin and cytarabine) relapsed at 4 months
Day et al [8].	4 mos/F		5.4 g/dL/leukocytes normal in number/86×10⁹/L	N/A	75% Erythroblasts	Positive for CD71, CD235a
Case 5	4 yrs/F	Pain abdomen, fever, pallor, hepatosplenomegaly	8.4 g/dL/N.A/70×10⁹/L	N/A	77% Erythroblasts	Positive for CD71, CD11b	Complex 48-51, XX, der(1)t(1;6)(q10;q12), +i(1)(q10;q12), +7, del(13)(q32). Add (16)(q24), +18, +21 [25]/46.XX [2]	Died 1 month after initiation of induction chemotherapy
Day et al [8].	4 yrs/F	Pain abdomen, fever, pallor, hepatosplenomegaly	8.4 g/dL/N.A/70×10⁹/L	N/A	77% Erythroblasts	Positive for CD71, CD11b		Died 1 month after initiation of induction chemotherapy
Case 6	2 yrs/M	Proptosis and bleeding from left eye, fever	N/A	30% blasts and thrombocytopenia	90% Blasts	N/A	Complex	Relapsed at 6 months (cytarabine, doxorubicin and etoposide)
Bhattacharya et al [9].	2 yrs/M	Proptosis and bleeding from left eye, fever	N/A	30% blasts and thrombocytopenia	90% Blasts	N/A	Complex
Present case	15 yrs/F	Fever, increased bleeding per vaginal	6 g/dL/0.0×10⁹/L/112×10⁹/L	87% erythroids including proerythroblasts	90% erythroid cells with 60% proeythroblasts	Positive for CD71, CD235a (glycophorin A), CD36, CD34 (10% subset), and negative for other myeloid and lymphoid markers	46XX, add (4) (p16)	Alive, 3 months
Present case	15 yrs/F	Fever, increased bleeding per vaginal	6 g/dL/0.0×10⁹/L/112×10⁹/L	87% erythroids including proerythroblasts	90% erythroid cells with 60% proeythroblasts		46XX, add (4) (p16)	Post induction (Duanorubicin and Cytarabine)

HB: Haemoglobin; ANC: Absolute Neutrophil Count; PBS: Peripheral Blood Smear; BMA: Bone Marrow Aspirate; FCMI: Flow Cytometric Immunophenotyping; yrs: years; mos: months; F: female; M: male; N/A: Not Available.