Table 2.

Utilization of small-molecule NUAK1 and NUAK2 inhibitors in preclinical models of DIsease

Inhibitor	Preclinical model	Reference
HTH-01-015	Non–small cell lung cancer, hepatocellular carcinoma, colorectal cancer, pancreatic cancer, liver fibrosis	(40, 53, 59, 62, 88)
KI-301670	Pancreatic cancer	(63)
HTH-02-006	Glioma, hepatocellular carcinoma, prostate cancer, kidney fibrosis	(32, 52, 74, 87)
WZ4003	Non–small cell lung cancer, breast cancer, gastric cancer, bladder cancer, Alzheimer’s disease, kidney fibrosis	(20, 38, 39, 44, 57, 86, 87)
ON123300	Gastric cancer, acute myeloid leukemia	(57, 83)

List of small molecule inhibitors of NUAK and/or NUAK2 that have been used in in-vivo experiments.

NUAK, novel (nua) kinase.