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Recently described asymmetric distribution of PS across different leaflets of the NE in mammalian cells: the cytosolic leaflet of the ONM, the luminal leaflets of both ONM and INM, and the nucleoplasmic leaflet of the INM. Notably, the enrichment of PS in the INM in mammalian cells can drive PC synthesis via membrane recruitment of CCTα and Lipin1α in response to oleic acid loading.
