FIGURE 4.

Proteomics of the vesicular proteome of MOLM‐14 cells after pathway inhibition. (A) PCA based on the 3475 proteins quantified throughout the four conditions and their biological triplicates. Treatments were coloured as follows: 0.10% DMSO‐treated control cells (yellow), 2000 nM HPI‐1 (blue), 100 nM Creno (green) and 10 nM Creno + 50 nM HPI‐1 (grey). (B) Comparison of expression levels (z‐scores) of significantly up‐ or downregulated proteins upon treatment with 10 nM Creno + 50 nM HPI‐1 in comparison to 0.10% DMSO control with levels of those of the other treatments. (C) Pathway analysis of all treatments in comparison to the control. Pathways that have a NES < ‐1.8 or > 1.8 and a p value of < 0.05 for any of the four different treatments are shown in the plot.