Table 3.
Comparison of Laboratory Parameters and Indices as Indicators of In-Hospital Mortality in COVID-19 and Influenza A (H1N1) Pneumonia
| Characteristics | COVID-19 (n: 51) Median (Q1-Q3) |
Influenza A (H1N1) (n: 38) Median (Q1-Q3) |
||||
|---|---|---|---|---|---|---|
| Survivors (n=48) | Non-Survivors (n=3) | p | Survivors (n=33) | Non-Survivors (n=5) | p | |
| WBC-U/L | 6.20(4.41–8.31) | 13.02(11.70–14.53) | 0.006 | 10.76(7.85–14.06) | 14.02(9.94–16.08) | 0.218 |
| Neutrophil-mmol/L | 4.00(2.86–5.38) | 8.42(5.40–12.03) | 0.400 | 736(5.01–8.99) | 14.04(6.41–18.13) | 0.073 |
| Lymphocyte-U/L | 1.26(0.79–0.78) | 0.27(0.17–0.49) | 0.010 | 1.13(0.78–1.86) | 0.81(0.44–1.62) | 0.261 |
| Monocyte-mmol/L | 0.42(0.31–0.75 | 0.20(0.15–0.33) | 0.123 | 0.84(0.59–1.07) | 0.87(0.62–3.13) | 0.331 |
| RDW | 40.90(39.05–43.75) | 40.70(39.70–47.20) | 0.904 | 44.40(39.30–48.95) | 49.30(45.85–57.45) | 0.880 |
| MPV-fL | 10.15(9.65–10.70) | 11.07(10.53–11.88) | 0.143 | 10.20(9.95–10.60 | 12.50(10.25–12.90 | 0.063 |
| MCV-fL | 83.40(80.00–86.25) | 84.00(82.80–85.25) | 0.734 | 88.10(81.16–91.45) | 88.50(83.40–90.85 | 0.931 |
| PLT-103/µL | 222.50(177.50–248.50) | 179.00(152.50–198.50) | 0.215 | 220.00(180.00–277.00) | 317.00(143.00–380.00 | 0.650 |
| CRP-mg/l | 36.15(11.50–74.20) | 79.40(73.10–145.20) | 0.055 | 34.90(15.00–96.05) | 110.00(47.55–130.50) | 0.181 |
| LDH-U/L | 291.00(258.50–362.50) | 352.00(330.50–537.00) | 0.138 | 275.00(204.00–345.50) | 480.00(366.00–1099.00 | 0.013 |
| BUN-mg/dL | 28.50(22.50–38.00) | 65.00 (55.50–66.50) | 0.019 | 35.00(27.00–59.50) | 80.00(46.00–108.50) | 0.022 |
| TG-mg/dL | 156.00(127.00–200.00) | 200.00(1865.0–209.00) | 0.228 | 120.00(101.50–135.50) | 200.00(126.50–211.50) | 0.030 |
| Procalcitonin-µg/L | 0.04(0.00–0.11) | 0.22(0.14–1.45) | 0.061 | 0.20 (0.04–0.53) | 1.01(0.07–3.22) | 0.195 |
| Creatinine-mg/dL | 0.82(0.66–1.00) | 0.98(0.81–1.00) | 0.645 | 0.78(0.55–1.03) | 1.20(1.00–1.75) | 0.031 |
| Albumin-g/dL | 3.60(3.20–4.06) | 3.11(2.57–3.28) | 0.085 | 3.20(2.86–3.50) | 2.23(1.64–2.85) | 0.012 |
| Bilirubin-mg/dL | 0.36(0.20–0.46) | 0.33(0.31–0.51) | 0.587 | 0.30(0.20–0.55) | 0.42(0.30–1.49) | 0.148 |
| Uric acid-mg/dL | 3.38(3.45–5.01) | 3.10 (3.08–3.56) | 0.200 | 4.80(3.60–6.55) | 5.30(4.65–7.15) | 0.310 |
| NLR | 2.98(1.94–5.89) | 29.87(20.78–43.91 | 0.010 | 6.85(3.91–8.52) | 10.61(8.72–27.55 | 0.009 |
| PLR | 162.49(116.63–251.13) | 662.96(418.98–93.98) | 0.049 | 184.61(140.43–268.55 | 234.83(200.42–530.68 | 0.160 |
| MLR | 0.33(0.23–0.58) | 0.37(0.32–3.12) | 0.057 | 0.66(0.32–0.99) | 1.97(0.52–3.25) | 0.050 |
| CLR | 27.04(8.29–5.42 | 294.07(193.42–1465.78) | 0.016 | 29.67(8.68–111.03) | 164.19(36.54–238.75) | 0.115 |
| LMR | 2.99(1.70–4.20) | 2.70(1.43–3.15) | 0.357 | 1.509(1.007–3.087) | 0.50(0.31–1.90) | 0.049 |
| NMR | 7.53(5.98–14.41) | 42.10 (23.59–99.30) | 0.262 | 9.75(6.31–14.79) | 10.91(5.4–16.65) | 0.914 |
| RAR | 10.91(9.90–13.53) | 15.56(14.00–17.80) | 0.055 | 13.82(10.43–15.61) | 22.10(19.04–32.61) | 0.001 |
| CAR | 10.02(2.97–22.80 | 39.11(29.23–53.47) | 0.034 | 11.25(6.04–33.19) | 49.23(20.75–85.67) | 0.045 |
| BAR | 7.47(6.47–11.56) | 18.84(16.81–26.16) | 0.015 | 10.51(7.08–20.77) | 30.76(17.67–77.26) | 0.013 |
| NAR | 1.10(0.75–1.65) | 2.44(1.60–5.07) | 0.246 | 2.10(1.52–2.95) | 6.23(3.63–7.54) | 0.004 |
| AISI | 342.46(161.18–535.95) | 1037.53(666.11–2049.26) | 0.128 | 1213.03(415.71–2092.94) | 3779.57(1591.5814851.6) | 0.023 |
| SII | 627.20(425.4–1208.58) | 6512.75(3993.12–444.06) | 0.018 | 1393.30(804.37–2154.93 | 4202.25(2219.43–5277.85) | 0.023 |
| SIRI | 0.78(1.54–2.35) | 5.79(4.06–9.91) | 0.034 | 5.03(1.72–9.35) | 11.92(5.47–58.98) | 0.040 |
| CALLY | 0.11(0.04–0.39) | 4.60(2.69–5.45) | 0.012 | 0.25(0.05–0.70) | 1.12(0.61–3.23) | 0.049 |
| ALBI | −0.58(−0.76- −0.52) | −0.49(−0.56- −0.42) | 0.215 | −0.61(−0.73- −0.43) | −0.36(−0.57- −0.14) | 0.029 |
| HALP | 26.09(15.98–35.60) | 4.10(2.90–8.65) | 0.015 | 24.64(12.84–32.24 | 9.67(5.85–14.28) | 0.012 |
Note: P-value < 0.05 was considered statistically significant.
Abbreviations: WBC, white blood cell; RDW, red blood cell distribution width; MCV, mean corpuscular volume; MPV, mean platelet volume; PLT, platelets; CRP, C-reactive protein; LDH, laktat dehidrogenaz; BUN, blood urea nitrogen; TG, Triglyceride; NLR, neutrophil to lymphocyte ratio; PLR, platelet to lymphocyte ratio; MLR, lymphocyte to monocyte ratio; LCR, Lymphocyte–CRP ratio; CLR, CRP to lymphocyte ratio; LMR, Lymphocyte-to-monocyte ratio; RAR, RDW to albumin ratio; CAR, CRP to albumin ratio; BAR, BUN to albumin ratio; NAR, neutrophil to albumin ratio; AISI, aggregate index of systemic inflammation; SII, systemic immune-inflammation index; SIRI, systemic inflammation response index; CALLY, CRP-albumin–lymphocyte index; ALBI, Albumin–bilirubin skoru; HALP, albumin, lymphocyte, and platelet score.