Table 3.

Comparison of Associations Found Between Candidate Genetic Variants and Serum Etonogestrel Concentrations in the Prior Candidate Gene Study With Etonogestrel Contraceptive Implant Users (n=350)¹¹ With Findings From This Genome-Wide Association Study (n=880, Including 335 From the Prior Study)

Genetic Variant	Candidate Gene Study Findings		GWAS Study Findings
	β-coefficient*	P	β-coefficient	P
NR1I2 (PXR) rs2461817	13.36	.005	−0.60	.84
PGR rs537681	−29.77	.007	4.5	.15
CYP3A7*1C	−35.06	.025	−26.1	8.1×10−3

GWAS, genome wide association study.

^*Calculated using multivariable generalized linear modeling.¹¹