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. 2025 Sep 23;13:RP102756. doi: 10.7554/eLife.102756

Table 3. Moderated mediation analysis results for study 2.

In the moderated mediation model, IH serves as the independent variable, harm framing report as the mediator, relative harm sensitivity as the dependent variable, and decision context (gain vs. loss) as the moderator. Coefficient a represents the influence of the independent variable on the mediator, while coefficient b represents the effect of the mediator on the dependent variable, and coefficient c’ represents the direct effect (insignificant c’ suggests a full mediation effect). The coefficients in bold indicate the moderation effect of the context (gain vs. loss) in both the placebo and oxytocin sessions P<0.05, ∗∗P<0.01, and ∗∗∗P<0.001.

Predictors Placebo Oxytocin
Mediator Dependent variable Mediator Dependent variable
Harm framing report β (SE) Relative harm sensitivity β (SE) Harm framing report β (SE) Relative harm sensitivity β (SE)
Intercept 1.196 (0.279) *** 0.069 (0.023) ** 1.609 (0.239) *** 0.049 (0.014) ***
Context (gain vs. loss) –0.739 (0.396) –0108 (0.032) ** –0.196 (0.338) –0.002 (0.019)
Empathic concern (EC) 0.020 (0.046) 0.008 (0.004) * 0.023 (0.040) 0.005 (0.002) *
Impartial beneficence (IB) –0.116 (0.239) 0.010 (0.019) –0.270 (0.179) –0.008 (0.010)
Instrumental harm (IH) –0.758 (0.257) *** a –0.018 (0.016) c’ –0.753 (0.220) *** a –0.017 (0.011) c’
Context × IH 0.784 (0.343) * 0.137 (0.291)
Harm framing report 0.039 (0.008) *** b 0.028 (0.006) *** b