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. 2025 Sep 24;22(230):20250108. doi: 10.1098/rsif.2025.0108

Table 2.

Outputs from the input parameter optimization step for humans and mice without atRA feeding. Values in parentheses in the first three rows represent target values during the optimization of input parameter values, as listed in table 1. Quantities in the last three rows were not optimization targets but were computed due to their physiologic interest. See text for descriptions and definitions of individual parameters. Note that uCC=0LCqCdx.

parameter

mouse

human

IOP (mmHg)

14 (14.4)

14.9 (14.9)

unconventional outflow as a percentage of total outflow, Qu/Qprod (%)

19.9 (20)

20 (20)

average SA concentration in the sclera as a fraction of SA concentration in blood, <c2>S/c2,B

0.19 (0.19)

0.18 (0.19)

fluid outflow rate across the sclera per unit area, uS (m s−1)

1.75×10-7

0.41×10-8

fluid flow rate out of the choroidal capillaries per unit area, uCC (m s−1)

-0.6×10-7

-3.17×10-8

serum albumin leakage rate from the choroidal capillaries (mol s−1)

4.34×10-13

7.53×10-13