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. 2025 Sep 9;16:1631313. doi: 10.3389/fendo.2025.1631313

Table 2.

Protocols of controlled ovarian hyperstimulation and data of in vitro fertilization and embryo transfer (intention-to-treat analysis).

Characteristic No. (%) of participants P value
Intervention (n = 443) Control (n = 443)
Types of embryo transfer
 Fresh embryo transfer 159 (36.0) 168 (38.0) .54
 Frozen thawed embryo transfer 284 (64.0) 275 (62.0)
  Hormone replacement of frozen thawed embryo transfer 173 (60.5) 175 (63.5) .47
  Natural cycle of frozen thawed embryo transfer 111 (39.5) 100 (36.5)
Protocol of controlled ovarian hyperstimulation
 Ultralong GnRH agonist 42 (9.6) 52 (11.5) .73
 Long GnRH agonist 138 (31.4) 128 (29.0)
 Short GnRH agonist 56 (12.5) 55 (12.4)
 GnRH antagonist 207 (46.5) 208 (47.1)
Times of ET
 0 199 (44.9) 209 (47.2) .57
 1 131 (29.6) 120 (27.1)
 2 62 (14.0) 71 (16.0)
 3 or more 51 (11.5) 43 (9.7)
Number of embryos transferred
 1 93 (21.0) 87 (19.6) .58 a
 2 348 (78.6) 353 (79.7)
 3 2 (0.5) 3 (0.7)
Stage of embryos transferred
 Blastocyst stage 360 (81.1) 344 (77.6) .20
 Cleavage stage 83 (18.9) 99 (22.4)

GnRH, gonadotropin-releasing hormone; ET, embryo transfer.

a

Mann-Whitney U Test.