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. 2025 Aug 25;17(8):e90930. doi: 10.7759/cureus.90930

Table 5. GSTT1, GSTM1, and NQO1 genotype distribution in responders (complete + partial) and nonresponders.

* Statistically significant susceptible genotype

Gene polymorphism Responders (n = 105) Nonresponders (n = 95) p-Value OR (95% CI)
GSTT1 genotype
            Present 48 (45.7%) 62 (65.3%) - Reference
            Null 57 (54.3%) 33 (34.7%) 0.0068* 0.45 (0.25-0.79)
GSTM1 genotype
            Present 54 (51.4%) 59 (62.1%) - Reference
            Null 51 (48.6%) 36 (37.9%) 0.1536 0.65 (0.37-1.14)
NQO1 (CT + TT)
            CC (wild type) 84 (80.0%) 80 (84.2%) - Reference
            CT + TT 21 (20.0%) 15 (15.8%) 0.4665 0.75 (0.36-1.56)
NQO1 allele frequency
            C 184 (88.0%) 172 (90.5%) - Reference
            T 26 (12.0%) 18 (9.5%) 0.4243 0.74 (0.39-1.40)