Table 2.
Mendelian randomization estimates of the causal effect of epilepsy on stature and obesity using FinnGen data.
| Method | Number of SNPs | MR analysis | Heterogeneity test | MR-Egger intercept P | |||||
|---|---|---|---|---|---|---|---|---|---|
| OR | LCI | UCI | P | Cochran’s Q | I2 | P | |||
| Epilepsy (N = 64,629, Ncase = 27,559, Ncontrol = 42,436) on ISS (N = 3,62,599, Ncase = 6,11, Ncontrol = 3,61,988) | |||||||||
| IVW | 39 | 0.87 | 0.44 | 1.70 | .682 | 31.7 | 0.0 | .757 | – |
| MR-Egger | 39 | 0.77 | 0.08 | 7.61 | .828 | 31.6 | 0.0 | .718 | .918 |
| Weighted Median | 39 | 0.74 | 0.29 | 1.89 | .516 | – | – | – | – |
| Epilepsy (N = 64,629, Ncase = 27,559, Ncontrol = 42,436) on CTS (N = 3,62,116, Ncase = 128, Ncontrol = 3,61,988) | |||||||||
| IVW | 39 | 1.11 | 0.20 | 6.19 | .905 | 55.5 | 31.5 | .033 | – |
| MR-Egger | 39 | 5.30 | 0.01 | 2014.75 | .585 | 55.0 | 32.8 | .028 | .593 |
| Weighted Median | 39 | 1.96 | 0.21 | 18.08 | .540 | – | – | – | – |
| Epilepsy (N = 64,629, Ncase = 27,559, Ncontrol = 42,436) on Obesity (N = 500,192, Ncase = 31,499, Ncontrol = 4,68,693) | |||||||||
| IVW | 41 | 1.05 | 0.89 | 1.22 | .569 | 119.4 | 66.5 | .000 | – |
| MR-Egger | 41 | 1.10 | 0.63 | 1.90 | .740 | 119.3 | 67.3 | .000 | .859 |
| Weighted Median | 41 | 1.03 | 0.89 | 1.19 | .706 | – | – | – | – |
| GGE (N = 49,388, Ncase = 6952, Ncontrol = 42,436) on ISS (N = 3,62,599, Ncase = 611, Ncontrol = 3,61,988) | |||||||||
| IVW | 18 | 0.75 | 0.45 | 1.27 | .286 | 19.4 | 12.4 | .306 | – |
| MR-Egger | 18 | 0.43 | 0.01 | 14.31 | .647 | 19.3 | 17.0 | .254 | .758 |
| Weighted Median | 18 | 0.67 | 0.34 | 1.34 | .256 | – | – | – | – |
| GGE (N = 49,388, Ncase = 6952, Ncontrol = 42,436) on CTS (N = 3,62,116, Ncase = 128, Ncontrol = 3,61,988) | |||||||||
| IVW | 18 | 1.66 | 0.59 | 4.66 | .336 | 12.2 | 0.0 | .790 | – |
| MR-Egger | 18 | 627.74 | 0.66 | 5,98,000.00 | .084 | 9.2 | 0.0 | .904 | .105 |
| Weighted Median | 18 | 2.37 | 0.58 | 9.63 | .227 | – | – | – | – |
| GGE (N = 49,388, Ncase = 6952, Ncontrol = 42,436) on Obesity (N = 5,00,192, Ncase = 31,499, Ncontrol = 4,68,693) | |||||||||
| IVW | 18 | 0.99 | 0.92 | 1.06 | .708 | 16.5 | 0.0 | .490 | – |
| MR-Egger | 18 | 0.81 | 0.52 | 1.28 | .384 | 15.8 | 0.0 | .469 | .409 |
| Weighted Median | 18 | 1.02 | 0.93 | 1.12 | .706 | – | – | – | – |
| FE (N = 57,375, Ncase = 14,939, Ncontrol = 42,436) on ISS (N = 3,62,599, Ncase = 611, Ncontrol = 3,61,988) | |||||||||
| IVW | 28 | 1.88 | 0.94 | 3.75 | .073 | 24.5 | 0.0 | .603 | – |
| MR-Egger | 28 | 24.22 | 0.75 | 783.34 | .084 | 22.3 | 0.0 | .670 | .154 |
| Weighted Median | 28 | 2.01 | 0.80 | 5.03 | .154 | – | – | – | – |
| FE (N = 57,375, Ncase = 14,939, Ncontrol = 42,436) on CTS (N = 3,62,116, Ncase = 128, Ncontrol = 3,61,988) | |||||||||
| IVW | 28 | 0.53 | 0.08 | 3.36 | .502 | 42.4 | 36.3 | .030 | – |
| MR-Egger | 28 | 0.00 | 0.00 | 13.41 | .173 | 39.9 | 34.8 | .040 | .208 |
| Weighted Median | 28 | 0.19 | 0.02 | 1.76 | .142 | – | – | – | – |
| FE (N = 57,375, Ncase = 14,939, Ncontrol = 42,436) on Obesity (N = 5,00,192, Ncase = 31,499, Ncontrol = 4,68,693) | |||||||||
| IVW | 28 | 0.99 | 0.86 | 1.14 | .888 | 55.3 | 51.2 | .001 | – |
| MR-Egger | 28 | 0.86 | 0.43 | 1.73 | .682 | 55.0 | 52.7 | .001 | .696 |
| Weighted Median | 28 | 1.02 | 0.88 | 1.18 | .782 | – | – | – | – |
CTS = constitutional tall stature, FE = focal epilepsy, GGE = generalized genetic epilepsy, ISS = idiopathic short stature, LCI = lower confidence interval, MR = Mendelian randomization, OR = odds ratio, IVW = inverse-variance weighted, SNP = single nucleotide polymorphism, UCI = upper confidence interval.