Table 4.
Mendelian randomization estimates of the causal effect of epilepsy on obesity using pan-UKB data.
| Method | Number of SNPs | MR analysis | Heterogeneity test | MR-Egger intercept P | |||||
|---|---|---|---|---|---|---|---|---|---|
| OR | LCI | UCI | P | Cochran’s Q | I2 | P | |||
| Epilepsy (N = 64,629, Ncase = 27,559, Ncontrol = 42,436) on obesity (N = 4,20,531, Ncase = 15,917, Ncontrol = 4,04,614) | |||||||||
| IVW | 40 | 1.06 | 0.91 | 1.25 | .441 | 52.4 | 27.4 | .061 | – |
| MR-Egger | 40 | 0.64 | 0.38 | 1.08 | .106 | 57.8 | 32.5 | .027 | .055 |
| Weighted Median | 40 | 1.09 | 0.89 | 1.33 | .394 | – | – | – | – |
| GGE (N = 49,388, Ncase = 6952, Ncontrol = 42,436) on obesity (N = 4,20,531, Ncase = 15,917, Ncontrol = 4,04,614) | |||||||||
| IVW | 19 | 1.05 | 0.93 | 1.18 | .445 | 30.8 | 44.9 | .021 | – |
| MR-Egger | 19 | 1.05 | 0.56 | 1.97 | .872 | 30.8 | 41.6 | .030 | .985 |
| Weighted Median | 19 | 1.04 | 0.91 | 1.20 | .570 | – | – | – | – |
| FE (N = 57,375, Ncase = 14,939, Ncontrol = 42,436) on obesity (N = 4,20,531, Ncase = 15,917, Ncontrol = 4,04,614) | |||||||||
| IVW | 28 | 1.24 | 1.06 | 1.46 | .008 | 37.4 | 30.6 | .068 | – |
| MR-Egger | 28 | 1.39 | 0.72 | 2.66 | .337 | 37.6 | 28.2 | .084 | .734 |
| Weighted Median | 28 | 1.25 | 1.02 | 1.53 | .030 | – | – | – | – |
FE = focal epilepsy, GGE = generalized genetic epilepsy, IVW = inverse-variance weighted, LCI = lower confidence interval, MR = Mendelian randomization, OR = odds ratio, SNP = single nucleotide polymorphism, UCI = upper confidence interval.