Table 6.
Univariate and multivariate analysis of clinical factors and mutations associated with second recurrence in RAIR-DTC patients.
| Characteristics | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| OR | 95% CI | P-value | OR | 95% CI | P-value | |
| Age ≥ 55 | 1.2 | 0.4–3.5 | >.05 | 0.8 | 0.2–3 | >.05 |
| Male | 4.1 | 1.5–11.2 | <.01 | 4.4 | 1.3–15.2 | .02 |
| Tumor size T4 | 3.0 | 0.9–10.3 | >.05 | 1.2 | 0.3–5.1 | >.05 |
| Lympho note metastasis N1 | 1.2 | 0.4–4.0 | >.05 | 1.6 | 0.4–7.4 | >.05 |
| C-PTC | 0.9 | 0.3–3.1 | >.05 | 0.9 | 0.2–4.4 | >.05 |
| Surgical treatment | 15.9 | 1.6–161.9 | <.05 | 59.2 | 3.8–928.4 | .004 |
| BRAF+ and TERT+ | 5.0 | 1.7–14.3 | <.005 | 10.4 | 2.5–44.5 | .002 |
Bold values indicate statistical significance.
C-PTC = conventional papillary thyroid carcinoma, RAIR-DTC = radioiodine-refractory differentiated thyroid cancer, TERT = telomerase reverse transcriptase.