TABLE 2.
Mutations in VP1 that confer drug dependence
| Amino acid substitutiona | Codon mutation | Isolate no.b |
|---|---|---|
| V1210A | GUC→GCC | 2, 3,c 4,c 6, 7, 8, 9 |
| T1208A | ACU→GCU | 5 |
| M1103T | AUG→ACG | 1 |
a
The flanking letters represent the amino acid residues in the wild-type and mutant viruses, respectively; the first digit represents the capsid peptide (i.e., 1 for VP1); and the subsequent three digits represent the residues numbered 1 to 285 from the amino end.
b
See Table 1.
c
Harbors an additional mutation (E3081Q) which subsequently proved unrelated to drug dependence by site-directed mutagenesis.