Table 3.
Subgroup analyses of the effect of LDL-C/HDL-C ratio on stroke.
| Subgroup | N | Events, n(%) | HR(95%CI) | P for interaction |
|---|---|---|---|---|
| Sex | 0.547 | |||
| male | 5999 | 308 (5.2) | 1.48 (1.24, 1.78) | |
| female | 6894 | 223 (3.2) | 1.37 (1.09, 1.72) | |
| Age, years | 0.556 | |||
| <65 | 6431 | 183 (2.9) | 1.36 (1.08, 1.72) | |
| ≥65 | 6462 | 348 (5.3) | 1.47 (1.23, 1.76) | |
| BMI,kg/m2 | 0.668 | |||
| <24 | 7272 | 351 (4.8) | 1.46 (1.22, 1.75) | |
| ≥24 | 5621 | 180 (3.2) | 1.38 (1.08, 1.76) | |
| Smoking | 0.473 | |||
| never smokers | 7549 | 254 (3.4) | 1.36 (1.10, 1.69) | |
| former smokers | 1993 | 86 (4.3) | 1.51 (1.10, 2.07) | |
| current smokers | 3351 | 191 (5.7) | 1.50 (1.21, 1.86) | |
| Drinking | 0.024 | |||
| never drinkers | 8535 | 308 (3.7) | 1.28 (1.06, 1.55) | |
| former drinkers | 1628 | 80 (4.9) | 1.56 (1.11, 2.19) | |
| current drinkers | 2912 | 143 (4.9) | 1.76 (1.38, 2.25) | |
| Diabetes | 0.401 | |||
| no | 10632 | 421 (4.0) | 1.48 (1.25, 1.75) | |
| yes | 2261 | 110 (4.8) | 1.30 (0.96, 1.74) | |
| Dyslipidemia | 0.957 | |||
| no | 4092 | 188 (4.6) | 1.47 (1.08, 2.00) | |
| yes | 8801 | 343 (3.9%) | 1.46 (1.23, 1.74) |
Each subgroup analysis adjusted, if not stratified, for sex, age, BMI, WC, SBP, DBP, FPG, TC, TG, eGFR, Hcy, smoking, drinking, diabetes, dyslipidemia, CKD, CHD, AF, antiplatelet drugs, antihypertensive drugs, glucose-lowering drugs. The P-interaction was evaluated against the Bonferroni-corrected α value to minimize the risk of type I error.