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. 2025 Aug 26;7(1):ROEL2025. doi: 10.1539/eohp.ROEL2025

Table IV. Occupational sensitizers.

Airway
Group 1
 Beryllium*, Cobalt*, Colophony (Rosin)*, Diphenylmethane-4,4’-diisocyanate (MDI), Glutaraldehyde, Hexane-1,6-diisocyanate, Methyltetrahydrophthalic anhydride, o-Phthalaldehyde, Phthalic anhydride, Platinum*, Toluene diisocyanates*, Trimellitic anhydride
Group 2
 Chlorothalonil, Chromium*, Ethylenediamine, Formaldehyde, Maleic anhydride, Methyl methacrylate, Nickel*, Piperazine
Skin
Group 1
 Aniline, Benzoyl peroxide, 5-Chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one mixture, Chlorothalonil, Chromium*, Cobalt*, Colophony (Rosin)*, 2,4-Dinitrochlorobenzene (DNCB), Epichlorohydrin, Formaldehyde, Glutaraldehyde, Hydrazine*, Mercury*, 4,4’-Methylenedianiline, Nickel*, p-Phenylenediamine, o-Phthalaldehyde, Platinum*, Resorcinol, Sodium ethylmercury 2-Sulfidobenzoate (Thimerosal), Thiuram, Trichloroethylene, Tri (propylene glycol) diacrylate, N,N’,N’’-Tris (β-hydroxyethyl)-hexahydro-1,3,5-triazine, Turpentine*, m-Xylylendiamine
Group 2
 Acrylamide, Benomyl, 1,2-Benzothiazolin-3-one, Benzyl alcohol, Beryllium*, Butyl acrylate, N-butyl-2,3-epoxy-propyl ether, 2-butyl-1,2-benzisothiazolin-3-one, Copper*, Dibutyl phthalate, Dichloropropane, Dicyclohexylcarbodiimide, Diethanolamine, 2,3-Epoxypropyl methacrylate (Glycidyl methacrylate, GMA), Ethyl acrylate, Ethylenediamine, Ethylene glycol dimethacrylate, Ethylene oxide, Fenitrothion, 1,6-Hexanediol diacrylate, Hydroquinone, 2-Hydroxyethyl acrylate, 2-Hydroxyethyl methacrylate, Iodine*, Maleic anhydride, Methyl acrylate, 2-Methyl-4-isothiazolin-3-one, Methyl methacrylate, 2-n-octyl-4-isothiazolin-3-one, Picric acid, Polyvinyl chloride plasticizers*, Rodium*, Toluene diamine*, Toluene diisocyanates*, Usnic acid
Group 3
m-Chloroaniline, Dimethylamine, Isophoronediisocyanate, o-Phenylenediamine, m-Phenylenediamine

*Evaluation does not necessarily apply to all individual chemicals within the group. Provisional.

The revised definition of “Occupational sensitizer” has been applied to the substances proposed in 1998 or later, and the substances listed before 1998 are not fully re-examined at this time; please note that OEL values are not necessarily recommended for all the substances listed here. See JSOH web site for brief summary of OEL documentation at https://www.sanei.or.jp/english/oels/index.html