Table 2.
Factors associated with mortality (univariate and multivariate Cox regression models)
| Univariate | Multivariate | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Model 1(1) | Model 2(2) | ||||||||
| HR | (95% CI) | p | HR | (95% CI) | p | HR | (95% CI) | p | |
| Patient age (< 80 years) | 2.25 | (1.59; 3.20) | 0.000 | 2.22 | (1.61; 3.06) | 0.000 | 2.08 | (1.62; 2.69) | 0.000 |
| Patient sex (female) | 1.18 | (0.76; 1.85) | 0.462 | ||||||
| Patient studies (≥ secondary) | 1.18 | (0.99; 1.40) | 0.072 | ||||||
| Barthel index (independence, little or moderate dependence, > 60 points) | 2.95 | (1.97; 4.41) | 0.000 | ||||||
| GDS stage (GDS 3–5 mild-moderate dementia) | 2.97 | (1.18; 7.45) | 0.020 | 3.40 | (1.45; 7.98) | 0.005 | 3.38 | (1.34; 8.52) | 0.010 |
| Treatment for dementia (No) | 0.63 | (0.38; 1.05) | 0.078 | ||||||
| Neuroleptic treatment (No) | 1.16 | (1.05; 1.28) | 0.003 | ||||||
| Charlson index (≤ 2 points) | 1.62 | (1.39; 1.90) | 0.000 | 1.67 | (1.29; 2.17) | 0.000 | 1.78 | (1.40; 2.26) | 0.000 |
| Apathy subsyndrome (No)(1) | 1.71 | (1.63; 1.80) | 0.000 | 1.66 | (1.47; 1.87) | 0.000 | |||
| Hyperactivity subsyndrome (No)(1) | 0.82 | (0.35; 1.89) | 0.638 | ||||||
| Affective subsyndrome (No)(1) | 1.30 | (0.96; 1.75) | 0.091 | ||||||
| Psychosis subsyndrome (No)(1) | 1.68 | (1.37; 2.06) | 0.000 | ||||||
| NPI Scale (≤ 21 points) | 1.54 | (1.05; 2.26) | 0.026 | 1.47 | (1.38; 1.58) | 0.000 | |||
In bold: p statistically significant. GDS Global Deterioration Scale (GDS 3: mild CD, borderline impairment. GDS 4: moderate CD, mild dementia. GDS 5: moderately severe CD, moderate dementia. GDS 6: severe CD, moderately severe dementia. GDS 7: very severe CD, severe dementia)
1Cox regression model adjusted for the presence of neuropsychiatric subsyndromes clinically relevant (that is, they have at least some neuropsychiatric symptoms with an NPI value ≥ 4)
AIC: 512.35
BIC: 515.17
2Cox regression model adjusted for total NPI score
AIC: 513.88
BIC: 516.70