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. 2025 Sep 24;25:1427. doi: 10.1186/s12885-025-14477-2

Table 2.

Direct and indirect targets of hydralazine and ATRA, along with the probability of binding for each drug

Drugs Interaction Target names Confidence
Hydralazine Direct Tyrosine-protein kinase receptor FLT3 0.8759
Cell division cycle 2-like protein kinase 6 0.6967
Mediated Cytochrome P450 3A4 0.6882
Nuclear receptor subfamily 0 group B member 1 0.4936
ATRA Direct Retinoic acid receptor 0.7789
Cytochrome P450 2C9 0.5903
Mediated Solute carrier organic anion transporter family member 1B3 0.5228
Nuclear receptor subfamily 0 group B member 1 0.5204