Table 2.
Direct and indirect targets of hydralazine and ATRA, along with the probability of binding for each drug
| Drugs | Interaction | Target names | Confidence |
|---|---|---|---|
| Hydralazine | Direct | Tyrosine-protein kinase receptor FLT3 | 0.8759 |
| Cell division cycle 2-like protein kinase 6 | 0.6967 | ||
| Mediated | Cytochrome P450 3A4 | 0.6882 | |
| Nuclear receptor subfamily 0 group B member 1 | 0.4936 | ||
| ATRA | Direct | Retinoic acid receptor | 0.7789 |
| Cytochrome P450 2C9 | 0.5903 | ||
| Mediated | Solute carrier organic anion transporter family member 1B3 | 0.5228 | |
| Nuclear receptor subfamily 0 group B member 1 | 0.5204 |