Table 1.
Inhibition of cancer cell growth in three human cancer cell lines, determined by the MTT assay (exposure time: 96 h).
| Compound | A549 (μM) | SW480 (μM) | CH1 (μM) | |
|---|---|---|---|---|
| Ru |
3a
1a [5] |
11 ± 1 24 ± 4∗ |
5.4 ± 1.1 9.5 ± 0.7∗ |
1.9 ± 0.1 3.0 ± 0.9∗ |
|
3b
1b [5] |
20 ± 3 16 ± 1∗ |
7.9 ± 1.5 8.6 ± 0.9∗ |
2.8 ± 0.2 3.4 ± 0.2∗ |
|
|
3c
1c [5] |
> 200 12 ± 1∗ |
> 200 5.1 ± 0.4∗ |
102 ± 11 1.6 ± 0.4∗ |
|
|
3d
1d [5] |
7.2 ± 1.0 34 ± 3∗ |
3.8 ± 0.3 19 ± 2∗ |
1.61 ± 0.04 14 ± 2∗ |
|
|
3e
1e [5] |
14 ± 1 27 ± 1∗ |
5.5 ± 2.2 17 ± 1∗ |
1.8 ± 0.3 7.3 ± 0.4∗ |
|
|
| ||||
| Os |
4a
2a [5] |
12 ± 1 17 ± 1∗ |
5.9 ± 1.9 9.3 ± 1.1∗ |
2.3 ± 0.2 3.0 ± 0.2∗ |
|
4b
2b [5] |
20 ± 2 10 ± 1∗ |
7.4 ± 2.3 7.1 ± 0.3∗ |
2.7 ± 0.2 2.0 ± 0.4∗ |
|
|
4c
2c [5] |
> 200 10 ± 1∗ |
> 200 4.4 ± 0.5∗ |
> 200 0.83 ± 0.14∗ |
|
|
4d
2d [5] |
7.1 ± 0.6 17 ± 1∗ |
3.4 ± 0.9 9.3 ± 1.6∗ |
1.2 ± 0.2 3.7 ± 0.6∗ |
|
|
4e
2e [5] |
24 ± 1 14 ± 1∗ |
8.1 ± 2.6 7.1 ± 1.2∗ |
2.1 ± 0.5 2.2 ± 0.3∗ |
|
Note: 50% inhibitory concentrations (means ± standard deviations) from at least three independent experiments.
∗IC50 values of the chlorido complexes were added as reference [5].