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Cellular accumulation of compounds 3a–e (50 μM, 0.5% DMF in MEM) in SW480 cancer cells (exposure time: 2 h) and calculated logP (clogP) values of the corresponding free ligands.
| Compound | fg Ru/cell | clogP (free ligand) | Solubility (mM) |
|---|---|---|---|
| 3a | 387 ± 16 | 2.54 | 9.08 |
| 3b | 470 ± 71 | 2.71 | 8.82 |
| 3c | 4.6 ± 0.6 | 1.41 | 24.6 |
| 3d | 477 ± 47 | 2.99 | 8.92 |
| 3e | 246 ± 47 | 2.60 | 15.6 |
