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. 2025 Sep 12;15:1674548. doi: 10.3389/fonc.2025.1674548

Table 2.

Summary of previous cases associated with gastrointestinal bleeding and prostate cancer.

Age Case symptoms Medical history Main diagnosis Gleason score Treatment Prognosis Reference
61 Lower gastrointestinal bleeding, rectal pain, and psoriasiform dermatitis BPH; hypertension Metastatic prostate cancer (bone metastasis) 8 ADT, radiotherapy, and chemotherapy Clinical improvement, including decreased rectal bleeding, resolution of skin lesions, and no adverse effects (10)
76 Upper gastrointestinal bleeding and melena Metastatic prostate cancer (bone metastasis) ·Metastatic prostate cancer (bone metastasis);
·Secondary duodenal carcinoma
Unknown Unknown Death occurred after 1 month due to septic shock (11)
77 Epistaxis, hemoptysis, hematuria, hematemesis, and hemorrhagic shock Unknown ·Metastatic prostate cancer (bone metastasis);
·Cancer-related DIC
7 ·ADT, abiraterone acetate;
·Anticoagulation, platelet replacement, coagulation factors, and fibrinogen
Death occurred after 6 months (12)
81 Altered mental status, aphasia, and left-sided hemiparesis, coffee ground emesis Prostate cancer; hypertension ·Metastatic prostate cancer (bone metastasis);
·Gastric metastasis
Unknown ADT, endoscopic hemostasis treatment Death occurred after his family decided to withdraw care (13)

BPH, Benign prostatic hyperplasia; ADT, Androgen deprivation therapy; DIC, Disseminated intravascular coagulation.