Table 6.
Design of AuNPs for the treatment of ovarian cancer (drug delivery).
| No | Particle size | Surface functionalization of AuNPs | Drug | Highlights of Study | Animal model | Toxic | Reference |
|---|---|---|---|---|---|---|---|
| 1 | ~10nm | Covalent bonding | DTX | Plasmonic photothermal therapy (PPTT) enables pH-triggered controlled release of docetaxel by disrupting halloysite nanotube (HNT) interlayer hydrogen bonds via Au nanoparticle-mediated photothermal effects | – | The MTT results indicate low toxicity in 3T3 | (115) |
| 2 | ~13nm | Thiolation; Covalent bonding | CALNN;Linalool | GSH-capped linalool delivery; CALNN peptide conjugation; Caspase-8/p53 activation & NF-κB inhibition | – | Considered | (120) |
| 3 | ~40nm | Thiolation | NDC - 1;NDC - 2 | Thiol-Au conjugated naproxen derivatives; Simple high-loading platform; 5× lower IC50 vs free drugs | – | Considered | (121) |
| 4 | ~13nm | Thiolation | DOX | DNA-hybridized Dox loading; pH-responsive release; 2.5× greater in vivo suppression vs free Dox | BALB/c nude mice | Considered | (118) |
| 5 | ~20nm | – | auroliposome | AuNP-embedded siRNA liposomes; Caveolae-mediated uptake enhancement; PDX model efficacy | – | No toxicity | (119) |
| 6 | 12 ± 2 nm | Thiolation | miR - 145 | FSH receptor-targeted delivery via FSH33 peptide | – | Considered | (122) |
| 7 | ~30nm | Electrostatic adsorption; Covalent bonding; Thiolation | PTX | Multimodal imaging (PA/FL/CT); pH-responsive PTX release; Photothermal-enhanced delivery | mice | Considered | (123) |
| 8 | ~10nm | – | DTX | HNT/AuNP/SORT antibody integration; PPTT/pH-triggered release (44 °C activation); Selective cancer killing | – | The MTT results indicate low toxicity in 3T3 | (115) |
| 9 | 10~15nm | – | TXT | Ca(OH)2 tumor-penetration pretreatment; Magnetic/PPTT/CT multifunctional system; 89% growth inhibition | mice | The MTT results indicate low toxicity in 3T3 | (28) |
| 10 | 60 ± 5nm*30 ± 3nm | Thiolation; Covalent bonding | CSA-131 | Peanut-shaped AuNP delivery of ceragenin; Systemic administration potential | BALB/c nude mice | No toxicity | (124) |
| 11 | ~19nm | Thiolation; Covalent bonding | TfQ | Theaflavin-mediated synthesis/stabilization; Low hemolytic nanocomposite | – | No toxicity | (125) |
| 12 | ~10nm | Thiolation | TZ; miR-200c | First integration of miR-200c with AuNPs-TZ nanocomplexes demonstrated. | – | Considered | (126) |
| 13 | ~20nm | Thiolation | DOX | QbD-guided functionalization yielded pH/NIR-responsive AuNPs-L-Dox nanoplatform for selective tumor drug release with reduced systemic toxicity | – | Low toxicity | s(127) |