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. 2025 Sep 25;15:32865. doi: 10.1038/s41598-025-18241-1

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© The Author(s) 2025

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 1 — Effects of Astragalus membranaceus and Salvia miltiorrhiza (AS) on blood pressure and renal function in SHRs. The trends of systolic and diastolic blood pressure in rats of each group before drug administration (A) and at 2 weeks (B), 4 weeks (C), 6 weeks (D), and 8 weeks (E) after drug administration.Bar graphs of urinary ALB (F), urinary NAG (G), serum Cys-c (H), serum ET-1 (I), serum AngII (J), serum Enos (K), and serum NO (L) levels in rats of each group. Data are presented as the mean ± SD (n = 6). ^## p < 0.01, ^#### p < 0.0001 compared with the Normal group, * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 compared with the Model group.