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. 2025 Sep 25;15:32865. doi: 10.1038/s41598-025-18241-1

Table 2.

DE mRNA reversed after AS intervention.

M vs. N AS vs. M
ID Name log2FC P-value Up/down log2FC P-value Up/down
ENSRNOG00000000036 Klhdc8a 7.25E-01 3.38E-08 Up −6.15E-01 3.39E-03 Down
ENSRNOG00000019481 Cyp8b1 4.58E + 00 5.68E-55 Up −7.23E-01 4.58E-05 Down
ENSRNOG00000061844 AABR07005618.1 1.36E + 00 1.69E-22 Up −6.73E-01 2.52E-07 Down
ENSRNOG00000061544 Spock2 2.32E + 00 7.07E-20 Up −8.75E-01 4.87E-03 Down
ENSRNOG00000047894 Liph 1.73E + 00 7.21E-19 Up −1.02E + 00 2.66E-03 Down
ENSRNOG00000001452 Fzd9 2.10E + 00 5.83E-18 Up −2.08E + 00 8.07E-08 Down
ENSRNOG00000029980 Zbtb16 2.13E + 00 1.17E-15 Up −1.35E + 00 3.23E-07 Down
ENSRNOG00000019206 Nupr1 1.06E + 00 2.03E-15 Up −1.02E + 00 3.29E-04 Down
ENSRNOG00000057855 F5 1.31E + 00 5.43E-15 Up −1.00E + 00 7.92E-04 Down
ENSRNOG00000005957 Slc4a7 1.33E + 00 8.17E-14 Up −1.49E + 00 6.66E-07 Down
ENSRNOG00000013547 Slc6a12 1.63E + 00 1.58E-13 Up −1.71E + 00 5.09E-04 Down
ENSRNOG00000008000 Syt13 1.56E + 00 3.18E-12 Up −1.50E + 00 2.80E-05 Down
ENSRNOG00000048224 AABR07035224.1 9.19E + 00 3.64E-10 Up −9.01E + 00 2.93E-09 Down
ENSRNOG00000019216 Il12rb1 1.57E + 00 5.38E-10 Up −1.38E + 00 7.45E-03 Down
ENSRNOG00000053631 Tdrd9 1.21E + 00 6.66E-10 Up −7.32E-01 5.20E-03 Down
ENSRNOG00000059789 Metazoa_SRP Inf 7.31E-10 Up Inf 7.91E-09 Down
ENSRNOG00000058739 Snn 7.40E-01 1.26E-09 Up −6.70E-01 9.26E-06 Down
ENSRNOG00000030285 Epha3 1.70E + 00 1.29E-09 Up −1.16E + 00 4.88E-04 Down
ENSRNOG00000049642 Smim5 2.00E + 00 1.88E-09 Up −1.99E + 00 7.59E-06 Down
ENSRNOG00000008223 Cnr1 1.36E + 00 2.75E-09 Up −1.09E + 00 4.41E-04 Down
ENSRNOG00000007687 Sema7a 1.29E + 00 3.97E-09 Up −1.04E + 00 1.08E-04 Down
ENSRNOG00000007989 Chst1 1.15E + 00 4.24E-09 Up −6.35E-01 3.43E-03 Down
ENSRNOG00000056955 Bicdl1 1.29E + 00 5.75E-09 Up −1.21E + 00 1.83E-07 Down
ENSRNOG00000004341 LOC498222 8.72E-01 9.20E-09 Up −9.78E-01 1.56E-03 Down
ENSRNOG00000005404 Rasgrp1 8.19E-01 1.35E-08 Up −6.67E-01 3.79E-04 Down
ENSRNOG00000015418 Klhl14 7.88E-01 2.62E-08 Up −6.04E-01 1.95E-03 Down
ENSRNOG00000000609 Ipmk 8.69E-01 3.96E-08 Up −6.37E-01 3.24E-05 Down
ENSRNOG00000012482 Ndrg4 8.44E-01 6.00E-08 Up −1.59E + 00 1.83E-15 Down
ENSRNOG00000026065 Slit1 9.80E-01 9.29E-08 Up −6.85E-01 3.29E-04 Down
ENSRNOG00000003929 Pcdh19 6.93E-01 2.51E-07 Up −6.42E-01 5.85E-03 Down
ENSRNOG00000011334 Tmem63c 1.48E + 00 3.74E-07 Up −1.09E + 00 2.40E-04 Down
ENSRNOG00000011858 Unc5d 1.16E + 00 4.74E-07 Up −8.97E-01 4.56E-03 Down
ENSRNOG00000048769 Nek5 1.11E + 00 5.11E-07 Up −1.07E + 00 1.09E-03 Down
ENSRNOG00000049382 AABR07071905.1 Inf 5.84E-07 Up Inf 1.49E-06 Down
ENSRNOG00000058664 Usp9y Inf 5.86E-07 Up −6.37E + 00 9.01E-06 Down
ENSRNOG00000011424 Cldn23 1.13E + 00 7.34E-07 Up −1.45E + 00 1.24E-05 Down
ENSRNOG00000016505 Fam169a 8.56E-01 8.63E-07 Up −7.73E-01 3.48E-04 Down
ENSRNOG00000046615 AABR07064724.1 8.17E + 00 1.04E-06 Up −7.98E + 00 5.46E-06 Down
ENSRNOG00000054212 Pde1a 6.21E-01 3.21E-06 Up −6.02E-01 1.56E-02 Down
ENSRNOG00000001284 Uncx 1.70E + 00 3.27E-06 Up −1.22E + 00 2.50E-03 Down
ENSRNOG00000011815 Sgk1 1.12E + 00 3.82E-06 Up −7.43E-01 2.82E-03 Down
ENSRNOG00000007387 Per1 1.08E + 00 3.91E-06 Up −6.14E-01 1.43E-02 Down
ENSRNOG00000058314 AABR07022162.2 1.54E + 00 7.27E-06 Up −8.11E-01 2.45E-02 Down
ENSRNOG00000028708 Ntsr1 Inf 1.09E-05 Up −3.24E + 00 7.54E-04 Down
ENSRNOG00000012181 Lpl 7.95E-01 1.41E-05 Up −8.54E-01 1.32E-03 Down
ENSRNOG00000010259 Esrrb 7.19E-01 1.70E-05 Up −5.92E-01 4.49E-03 Down
ENSRNOG00000005307 Slc4a10 1.39E + 00 1.81E-05 Up −1.09E + 00 3.98E-02 Down
ENSRNOG00000028404 Ppp1r1b 8.95E-01 1.97E-05 Up −7.83E-01 1.31E-05 Down
ENSRNOG00000051920 U1 9.36E-01 2.55E-05 Up −7.82E-01 2.84E-05 Down
ENSRNOG00000013330 Cdhr1 1.34E + 00 2.90E-05 Up −1.37E + 00 3.97E-04 Down
ENSRNOG00000007402 AC121415.1 1.35E + 00 4.18E-05 Up −1.05E + 00 2.74E-03 Down
ENSRNOG00000028225 Tnni3k 1.01E + 00 4.21E-05 Up −9.95E-01 2.64E-02 Down
ENSRNOG00000014710 Prom2 6.78E-01 5.42E-05 Up −6.00E-01 4.23E-04 Down
ENSRNOG00000014296 Syt10 3.05E + 00 7.33E-05 Up −2.78E + 00 6.12E-04 Down
ENSRNOG00000011526 Pcsk6 9.35E-01 7.97E-05 Up −1.20E + 00 2.72E-03 Down
ENSRNOG00000031126 Tecta 9.56E-01 1.03E-04 Up −6.27E-01 2.06E-02 Down
ENSRNOG00000060441 U1 8.71E-01 1.04E-04 Up −9.55E-01 3.13E-08 Down
ENSRNOG00000000515 Mapk13 7.78E-01 1.06E-04 Up −6.03E-01 1.69E-03 Down
ENSRNOG00000025625 Rnase4 1.04E + 00 1.46E-04 Up −6.63E-01 3.02E-02 Down
ENSRNOG00000003064 Bst1 8.37E-01 2.15E-04 Up −1.35E + 00 7.02E-06 Down
ENSRNOG00000059225 AABR07020987.1 1.30E + 00 3.06E-04 Up −7.45E-01 4.01E-02 Down
ENSRNOG00000036777 Wfdc16 2.45E + 00 3.09E-04 Up −2.17E + 00 2.87E-03 Down
ENSRNOG00000017234 Olr155 2.06E + 00 3.12E-04 Up −1.70E + 00 3.08E-03 Down
ENSRNOG00000054722 U1 8.77E-01 3.30E-04 Up −8.22E-01 8.59E-04 Down
ENSRNOG00000005367 Slc12a1 6.30E-01 4.37E-04 Up −6.45E-01 1.65E-03 Down
ENSRNOG00000028015 Pf4 1.23E + 00 4.53E-04 Up −7.23E-01 4.95E-02 Down
ENSRNOG00000022419 Dok7 1.02E + 00 6.26E-04 Up −1.03E + 00 1.19E-03 Down
ENSRNOG00000023008 Fam131c 8.53E-01 8.04E-04 Up −1.12E + 00 8.89E-04 Down
ENSRNOG00000061082 U1 8.42E-01 8.48E-04 Up −1.12E + 00 3.10E-03 Down
ENSRNOG00000039107 Mfrp 1.87E + 00 9.41E-04 Up −1.97E + 00 6.55E-03 Down
ENSRNOG00000021088 Tmod4 7.80E-01 1.16E-03 Up −6.73E-01 1.15E-02 Down
ENSRNOG00000019134 Htr4 3.11E + 00 1.23E-03 Up Inf 6.44E-05 Down
ENSRNOG00000005335 Galnt13 2.50E + 00 2.10E-03 Up −1.70E + 00 2.05E-02 Down
ENSRNOG00000057141 RGD1561730 1.81E + 00 2.10E-03 Up −1.19E + 00 3.76E-02 Down
ENSRNOG00000018505 Cidea 1.15E + 00 2.19E-03 Up −7.72E-01 1.07E-02 Down
ENSRNOG00000052128 Clec2e 3.09E + 00 2.25E-03 Up −1.82E + 00 3.12E-02 Down
ENSRNOG00000008936 Map3k6 8.38E-01 2.73E-03 Up −1.11E + 00 7.86E-04 Down
ENSRNOG00000019890 Folr2 1.20E + 00 3.04E-03 Up −6.43E-01 4.84E-02 Down
ENSRNOG00000045998 Sema6b 7.58E-01 3.12E-03 Up −6.94E-01 1.26E-02 Down
ENSRNOG00000054453 AABR07072511.1 Inf 3.29E-03 Up −3.21E + 00 1.95E-02 Down
ENSRNOG00000054419 U1 7.80E-01 3.41E-03 Up −6.07E-01 2.29E-02 Down
ENSRNOG00000054764 Flt3 7.85E-01 3.53E-03 Up −6.58E-01 1.93E-02 Down
ENSRNOG00000021128 Kcnj11 7.43E-01 3.55E-03 Up −7.35E-01 1.09E-02 Down
ENSRNOG00000012972 Alox5 1.11E + 00 3.55E-03 Up −1.01E + 00 3.45E-02 Down
ENSRNOG00000015368 Pdilt 9.94E-01 4.20E-03 Up −9.04E-01 2.05E-02 Down
ENSRNOG00000017456 Vstm2b 1.86E + 00 4.22E-03 Up −2.40E + 00 6.27E-04 Down
ENSRNOG00000061304 Atp2b3 6.02E-01 5.41E-03 Up −6.89E-01 3.80E-03 Down
ENSRNOG00000023337 Sema3a 6.21E-01 5.84E-03 Up −8.51E-01 4.76E-03 Down
ENSRNOG00000052027 U5 1.84E + 00 5.87E-03 Up −1.34E + 00 4.99E-03 Down
ENSRNOG00000059092 Olr154 1.37E + 00 6.06E-03 Up −1.52E + 00 5.62E-03 Down
ENSRNOG00000061399 AABR07024955.1 2.23E + 00 6.22E-03 Up −1.74E + 00 1.58E-02 Down
ENSRNOG00000030174 - 8.59E-01 6.86E-03 Up −6.40E-01 3.87E-02 Down
ENSRNOG00000026891 AC093995.1 Inf 8.52E-03 Up Inf 1.32E-02 Down
ENSRNOG00000019614 Ptpn22 8.51E-01 8.63E-03 Up −8.50E-01 2.52E-02 Down
ENSRNOG00000054952 U1 1.60E + 00 8.73E-03 Up −6.78E-01 3.03E-02 Down
ENSRNOG00000025453 Fam221b Inf 9.07E-03 Up −3.23E + 00 4.11E-02 Down
ENSRNOG00000051684 St8sia6 1.26E + 00 9.79E-03 Up −1.37E + 00 3.63E-03 Down
ENSRNOG00000019441 LOC108348086 1.58E + 00 1.09E-02 Up −1.40E + 00 2.86E-02 Down
ENSRNOG00000020142 Gdf1 Inf 1.17E-02 Up Inf 1.80E-02 Down
ENSRNOG00000010440 Gnal 6.11E-01 1.25E-02 Up −6.60E-01 1.71E-02 Down
ENSRNOG00000004502 Hal 3.51E + 00 1.31E-02 Up Inf 2.37E-03 Down
ENSRNOG00000013869 Kcnj4 1.31E + 00 1.31E-02 Up −2.18E + 00 2.95E-04 Down
ENSRNOG00000054989 Grhl1 9.05E-01 1.33E-02 Up −1.47E + 00 9.77E-04 Down
ENSRNOG00000015566 Atp6v1e2 2.07E + 00 1.44E-02 Up −2.31E + 00 1.12E-02 Down
ENSRNOG00000050998 Rn60_20_0047.3 Inf 1.60E-02 Up Inf 1.84E-02 Down
ENSRNOG00000013279 LOC681458 Inf 1.65E-02 Up Inf 2.11E-02 Down
ENSRNOG00000033244 LOC688473 Inf 1.65E-02 Up Inf 2.50E-02 Down
ENSRNOG00000007294 Sntg1 Inf 1.68E-02 Up Inf 1.76E-02 Down
ENSRNOG00000055311 U1 7.27E-01 2.10E-02 Up −8.43E-01 3.09E-11 Down
ENSRNOG00000057687 AC141334.3 2.57E + 00 2.56E-02 Up −2.37E + 00 2.86E-02 Down
ENSRNOG00000002057 Slc10a6 9.47E-01 2.65E-02 Up −9.69E-01 2.57E-02 Down
ENSRNOG00000011631 Fst 8.95E-01 3.00E-02 Up −1.72E + 00 2.18E-03 Down
ENSRNOG00000060475 AABR07001555.1 Inf 3.26E-02 Up Inf 3.34E-02 Down
ENSRNOG00000056358 Ccdc27 8.14E-01 3.84E-02 Up −1.01E + 00 1.61E-02 Down
ENSRNOG00000046600 AABR07015066.1 1.10E + 00 4.00E-02 Up −2.09E + 00 3.50E-05 Down
ENSRNOG00000060896 AABR07063424.1 1.03E + 00 4.24E-02 Up −1.86E + 00 5.44E-05 Down
ENSRNOG00000028238 Sh3bgr 9.50E-01 4.63E-02 Up −1.09E + 00 4.24E-02 Down
ENSRNOG00000059021 7SK 1.03E + 00 4.86E-02 Up −8.10E-01 2.92E-02 Down
ENSRNOG00000004918 Kcna4 −1.09E + 00 5.96E-05 Down 5.94E-01 4.61E-02 Up
ENSRNOG00000008915 Prima1 −2.07E + 00 2.81E-20 Down 1.47E + 00 3.31E-12 Up
ENSRNOG00000010079 Car3 −3.79E + 00 3.48E-04 Down 3.90E + 00 7.68E-08 Up
ENSRNOG00000008553 Mthfr −1.33E + 00 1.23E-11 Down 8.18E-01 4.04E-06 Up
ENSRNOG00000027350 Tns4 −7.60E-01 2.60E-04 Down 1.02E + 00 9.76E-06 Up
ENSRNOG00000015538 Abcd2 −1.16E + 00 4.90E-02 Down 1.60E + 00 5.70E-05 Up
ENSRNOG00000046022 LOC100911453 −1.84E + 00 1.93E-05 Down 1.83E + 00 9.16E-05 Up
ENSRNOG00000054637 AC115371.3 −9.81E-01 5.13E-05 Down 9.33E-01 1.22E-04 Up
ENSRNOG00000053604 7SK −2.53E + 00 1.26E-08 Down 1.18E + 00 1.64E-04 Up
ENSRNOG00000015075 Stc1 −6.42E-01 5.30E-05 Down 9.49E-01 1.96E-04 Up
ENSRNOG00000024651 Greb1 −6.18E-01 1.07E-04 Down 6.49E-01 2.18E-04 Up
ENSRNOG00000012674 Adrb3 Inf 7.41E-04 Down Inf 3.45E-04 Up
ENSRNOG00000015086 Plin1 −3.30E + 00 1.46E-06 Down 2.78E + 00 4.49E-04 Up
ENSRNOG00000008529 Foxs1 −1.23E + 00 2.55E-08 Down 8.18E-01 5.50E-04 Up
ENSRNOG00000032417 Gabrp −1.82E + 00 7.57E-21 Down 7.43E-01 1.13E-03 Up
ENSRNOG00000002937 Ren −1.22E + 00 3.96E-11 Down 6.41E-01 1.19E-03 Up
ENSRNOG00000009790 Kcnk3 −1.13E + 00 1.61E-02 Down 1.04E + 00 1.26E-03 Up
ENSRNOG00000051347 Rn50_13_0558.2 −1.24E + 00 2.24E-02 Down 1.52E + 00 1.84E-03 Up
ENSRNOG00000013552 Scd −4.84E + 00 3.72E-04 Down 2.55E + 00 2.05E-03 Up
ENSRNOG00000007290 Atp1a2 −1.41E + 00 1.65E-03 Down 9.63E-01 2.46E-03 Up
ENSRNOG00000042264 - −6.88E-01 1.35E-02 Down 8.40E-01 2.50E-03 Up
ENSRNOG00000002802 Cxcl1 −1.71E + 00 3.00E-04 Down 1.31E + 00 2.93E-03 Up
ENSRNOG00000059449 Metazoa_SRP −6.61E-01 1.75E-02 Down 7.00E-01 4.50E-03 Up
ENSRNOG00000022483 Trim50 −1.22E + 00 2.36E-05 Down 8.34E-01 4.88E-03 Up
ENSRNOG00000006263 Sh2d1a Inf 1.16E-02 Down Inf 4.94E-03 Up
ENSRNOG00000033564 Cfd −2.80E + 00 3.37E-03 Down 1.98E + 00 5.08E-03 Up
ENSRNOG00000004571 RGD1563680 −7.23E-01 1.57E-04 Down 6.30E-01 5.24E-03 Up
ENSRNOG00000032997 AY172581.20 −1.30E + 00 4.80E-03 Down 1.24E + 00 6.54E-03 Up
ENSRNOG00000025637 Saxo1 −2.18E + 00 1.86E-02 Down 2.46E + 00 7.50E-03 Up
ENSRNOG00000004649 Il1b −7.34E-01 1.61E-02 Down 8.97E-01 7.58E-03 Up
ENSRNOG00000031667 AY172581.11 −1.25E + 00 2.69E-02 Down 1.38E + 00 7.98E-03 Up
ENSRNOG00000057331 U1 −6.40E + 00 2.12E-19 Down 1.30E + 00 8.71E-03 Up
ENSRNOG00000000563 Adamts14 −1.17E + 00 3.79E-06 Down 7.26E-01 8.79E-03 Up
ENSRNOG00000001984 Kcne1 −1.70E + 00 7.87E-06 Down 9.57E-01 9.74E-03 Up
ENSRNOG00000060522 Metazoa_SRP Inf 1.42E-05 Down 6.60E-01 9.86E-03 Up
ENSRNOG00000002984 Bmp15 −1.26E + 00 4.03E-07 Down 6.68E-01 1.07E-02 Up
ENSRNOG00000009329 Nr1d1 −8.21E-01 2.54E-03 Down 7.15E-01 1.09E-02 Up
ENSRNOG00000015850 Rbp7 Inf 5.73E-03 Down Inf 1.10E-02 Up
ENSRNOG00000038738 LOC685203 −1.35E + 00 5.09E-12 Down 5.99E-01 1.19E-02 Up
ENSRNOG00000029055 Ttk −2.29E + 00 8.58E-06 Down 1.52E + 00 1.24E-02 Up
ENSRNOG00000008310 Mpo −4.31E + 00 2.25E-02 Down 4.00E + 00 1.26E-02 Up
ENSRNOG00000004698 Cd244 −2.24E + 00 3.44E-14 Down 8.90E-01 1.41E-02 Up
ENSRNOG00000001821 Adipoq −1.07E + 00 1.18E-03 Down 6.62E-01 1.43E-02 Up
ENSRNOG00000020620 Ppp1r32 −1.30E + 00 3.73E-03 Down 1.04E + 00 1.49E-02 Up
ENSRNOG00000008475 Fut9 −9.98E-01 1.60E-06 Down 6.06E-01 1.50E-02 Up
ENSRNOG00000012286 Il20ra −9.16E-01 8.38E-04 Down 7.34E-01 1.52E-02 Up
ENSRNOG00000015541 Gnb3 Inf 1.18E-06 Down Inf 1.75E-02 Up
ENSRNOG00000058824 - −2.77E + 00 1.25E-02 Down 1.08E + 00 1.83E-02 Up
ENSRNOG00000035576 Mir27b −1.41E + 00 1.75E-04 Down 9.93E-01 1.98E-02 Up
ENSRNOG00000054846 - −2.29E + 00 4.65E-02 Down 9.25E-01 2.00E-02 Up
ENSRNOG00000009705 Lck −6.61E-01 1.53E-02 Down 6.71E-01 2.00E-02 Up
ENSRNOG00000034190 - −5.98E-01 4.75E-03 Down 6.81E-01 2.17E-02 Up
ENSRNOG00000055675 SNORD94 −1.22E + 00 1.55E-04 Down 8.46E-01 2.19E-02 Up
ENSRNOG00000003925 Hhat −1.03E + 00 1.00E-04 Down 6.35E-01 2.56E-02 Up
ENSRNOG00000042781 Ropn1l −1.40E + 00 3.23E-04 Down 9.85E-01 2.74E-02 Up
ENSRNOG00000017716 Ucp3 Inf 1.15E-03 Down Inf 2.74E-02 Up
ENSRNOG00000014367 Ephb6 −1.10E + 00 7.67E-06 Down 7.31E-01 2.80E-02 Up
ENSRNOG00000008135 Pla2g4f −1.04E + 00 3.34E-02 Down 9.87E-01 2.81E-02 Up
ENSRNOG00000046377 Btnl9 −1.62E + 00 2.14E-02 Down 1.55E + 00 2.83E-02 Up
ENSRNOG00000017477 Mmp23 −5.99E-01 2.53E-02 Down 5.98E-01 2.84E-02 Up
ENSRNOG00000003580 Ucp1 Inf 1.46E-05 Down Inf 2.96E-02 Up
ENSRNOG00000060466 U3 −5.92E-01 3.94E-02 Down 1.41E + 00 3.12E-02 Up
ENSRNOG00000061945 Rn60_16_0690.2 Inf 4.66E-02 Down Inf 3.57E-02 Up
ENSRNOG00000025121 Pla2g3 Inf 2.50E-02 Down Inf 3.65E-02 Up
ENSRNOG00000015283 Nt5c1a −6.00E-01 1.36E-02 Down 6.18E-01 3.67E-02 Up
ENSRNOG00000013623 Amer2 −1.06E + 00 2.37E-05 Down 6.34E-01 3.92E-02 Up
ENSRNOG00000058726 AABR07054837.1 −8.03E-01 3.00E-02 Down 1.13E + 00 3.92E-02 Up
ENSRNOG00000026870 Clic6 −1.98E + 00 1.72E-02 Down 1.86E + 00 4.15E-02 Up
ENSRNOG00000012235 Ppp1r17 Inf 3.35E-02 Down Inf 4.48E-02 Up
ENSRNOG00000003841 Kcnh1 −7.82E-01 1.07E-02 Down 6.42E-01 4.52E-02 Up
ENSRNOG00000005180 Vstm2a −8.19E-01 2.30E-02 Down 8.99E-01 4.59E-02 Up
ENSRNOG00000027380 Upk1b −9.15E-01 8.01E-03 Down 7.37E-01 4.67E-02 Up
ENSRNOG00000062199 Rn60_20_0067.1 −1.47E + 00 5.28E-04 Down 9.96E-01 4.87E-02 Up
ENSRNOG00000050629 Olr312 −2.84E + 00 3.55E-03 Down 2.52E + 00 4.92E-02 Up