Table 3.
Sensitivity analyses for calculating incremental cost-effectiveness ratios during the within-trial period.
| Additional scenario analysis | Range of valuesa | Cost per mmHg SBPb changec ($) | Cost per QALYd gainedc ($) | ||||||||||
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|
|
Low | High | Low | High | ||||||||
| Changes in effectiveness-related parameters | |||||||||||||
|
|
Systolic blood pressure reduction, mmHge | 1.0-4.7 | 5.2 | 23.0 | N/Af | N/A | |||||||
|
|
Difference in QALYs between 2 groupse | 0.02-0.04 | N/A | N/A | 603.4 | 1206.8 | |||||||
|
|
Incremental mean medication adherence | 0.01-0.04 | 6.3 | 8.6 | 694.1 | 942.7 | |||||||
| Changes in cost-related parameters ($) |
|
|
|
|
|
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|
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Compensation for township physiciansg | 572.4-1717.1 | 8.1 | 8.8 | 805.5 | 870.3 | |||||||
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Compensation for village doctorsg | 5194.9-15554.9 | 5.4 | 11.2 | 539.4 | 1114.8 | |||||||
|
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Compensation for local project manager | 370.4-1111.1 | 8.2 | 8.5 | 812.7 | 855.9 | |||||||
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Compensation for county specialists | 134.65-403.95 | 8.3 | 8.4 | 823.5 | 837.9 | |||||||
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Voice messages | 774.4-2323.2 | 8.1 | 8.8 | 805.5 | 873.9 | |||||||
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Printing materials | 168.35-505.05 | 8.4 | 8.4 | 834.3 | 837.9 | |||||||
|
|
System maintenance and management costs per year | 740.7-2222.1 | 7.9 | 8.7 | 784.0 | 866.7 | |||||||
|
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Intervention development fee | 8248.8-24,746.4 | 3.8 | 13.0 | 381.2 | 1294.6 | |||||||
|
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Incremental annual medication cost | 2.6-7.8 | 7.5 | 12.9 | 692.6 | 975.1 | |||||||
|
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Incremental annual hospitalization cost | –48.6 to 16.2 | 4.8 | 16.7 | 298.7 | 1363.9 | |||||||
aThe range was defined as a 50% decrease or increase from the base case for key parameters, except for systolic blood pressure reduction and difference in QALYs between 2 groups.
bSBP: systolic blood pressure.
cCalculated based on the 5000 bootstrapping and adjusted for baseline outcome, township, sex, and age.
dQALY: quality-adjusted life year.
eRange values are the bounds of the 95% CIs from the primary outcome analysis in the SINEMA trial.
fNot applicable.
gPresented as the average cost for township physicians and village doctors including performance-based incentives.